PON3 (paraoxonase 3) belongs to the PON family of enzymes, which consists of three members. This gene is located on human chromosome 7q21-22. It has a wide range of expression. It is produced in liver, and has a molecular weight of ~40kDa.
Synonyms: Anti-Serum paraoxonase/lactonase 3
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: PON3 (paraoxonase 3) is responsible for delaying the oxidation of low-density lipoprotein (LDL) and cell oxidative stress. The protein products this enzyme generates, are associated with high-density lipoprotein (HDL), circulating in blood. The exact function of PON3 is not well understood. However, studies show that this enzyme acts like an antioxidant, and hydrolyses oxidized lipid peroxides. It also has lactonase activity. The serum concentrations of this protein are increased in HIV patients, and are related to the oxidative status. PON3 serum concentration is also elevated in atherosclerosis, and this results in decreased insulin sensitivity in peripheral artery disease, and inflammation in coronary artery disease.
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