OLIG2 (oligodendrocyte lineage transcription factor 2) is a transcription factor (TF) belonging to the basic-helix-loop-helix (bHLH) TF family. It is expressed in human glioblastoma and neural progenitor cells. It is a member of the Olig family, and has a predominant expression in ventral spinal cord of human embryo, during initial developmental stages. In spinal cord, it is essential for the maturation of oligodendrocyte progenitor cells.
Synonyms: Anti-Class B basic helix- loop-helix protein 1; Anti-Oligo2; Anti-Oligodendrocyte transcription factor 2; Anti-Protein kinase C-binding protein 2; Anti-Protein kinase C-binding protein RACK17; Anti-bHLHB1
Storage: -20C
Application: Anti-OLIG2 antibody produced in rabbit has been used in immunohistochemistry and western blotting.
Biochem Physiol Actions: OLIG2 (oligodendrocyte lineage transcription factor 2) is expressed in the pMN domain of the spinal cord, where the formation of motoneurons and differentiation of oligodendrocytes occur. Along with Olig1, another protein of the same family, Olig2 participates in specification of neurons, astrocytes, and oligodendrocytes. The gene is mapped to a region on chromosome 21 that has been implicated in learning deficits associated with Down syndrome. It is predominantly expressed in oligodendroglial tumors of the brain and serves as a biomarker for oligodendroglial tumor diagnosis.
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