The gene nucleoporin NUP35 is mapped to human chromosome 2q32.1. The protein is mainly present at the nuclear membrane.
Synonyms: Anti-35 kDa nucleoporin; Anti-MP-44; Anti-Mitotic phosphoprotein 44; Anti-Nuclear pore complex protein Nup53; Anti-Nucleoporin NUP53; Anti-Nucleoporin Nup35
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Nucleoporin NUP53 or NUP35 as the name suggests is a component of subcomplex of the nuclear pore complexes. It interacts with the neighboring nucleoporins NUP93, NUP155, NUP205 and the membrane protein NDC1. NUP35 together with other components is crucial for nuclear envelope assembly and exchange of macromolecules across the nuclear envelope.
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