Synonyms: Anti-MYH7; Anti-MyHC-alpha antibody produced in rabbit; Anti-Myosin heavy chain 6 antibody produced in rabbit; Anti-Myosin heavy chain, cardiac muscle alpha-isoform antibody produced in rabbit; Anti-Myosin-6 antibody produced in rabbit
Storage: -20C
Application: Anti-MYH6 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: MYH6 (myosin, heavy chain 6) gene encodes the a heavy chain subunit of the cardiac muscle myosin, which is a hexamer made up of two heavy chain subunits, two light chain subunits, and two regulatory subunits. It is involved in the contraction of muscles. Defects in this gene cause atrial septal defect 3 (ASD3) characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Mutations in this gene also cause familial hypertrophic cardiomyopathy that is characterized by ventricular hypertrophy, dyspnea, syncope, collapse, palpitations, and chest pain.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC