Multiple inositol-polyphosphate phosphatase 1 (MINPP1) is a phosphatase gene mapped to human chromosome 10q23.3. The encoded protein is localized in the endoplasmic reticulum (ER) lumen.
Synonyms: Anti-Inositol (1,3,4,5; Anti-Ins(1,3,4,5; Anti-Multiple inositol polyphosphate phosphatase 1
Storage: -20C
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Biochem Physiol Actions: Multiple inositol-polyphosphate phosphatase 1 (MINPP1) catalyzes the removal of 3-phosphate from inositol phosphate substrates. The protein might function as a low penetrance predisposition allele for follicular thyroid adenoma (FA) and carcinoma (FTC) and is associated with a subset of malignant follicular thyroid tumors. MINPP1 has an important role in the maintenance of cellular levels of inositol 1, 3, 4, 5, 6-pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) in vivo. Minpp1 might play an essential role in modulating endoplasmic reticulum (ER) stress and apoptosis.
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