MASP-2 (mannan-binding lectin-associated serine protease 2) is an important protein of the lectin pathway of complement, that is similar to the C1s and C1r serine proteases of the classical complement pathway. It is present on the chromosome 1p36.3-36.2. It consists of CUB1 (C1r/C1s, Uegf and bone morphogenetic protein-1 domains), EGF (epidermal growth factor), CUB2, CCP1 (complement control protein 1), CCP2 and SP (serine protease) domains.
Synonyms: Anti-MASP1P1; Anti-Mannan-binding lectin serine peptidase 2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Absence of MASP-2 (mannan-binding lectin-associated serine protease 2) plays a major role in the development of RA (rheumatoid arthritis) and articular symptoms among relatives of RA patients. In human lectin pathway, MASPs participates in the proteolysis of C4, C2 and C3, thereby activating the complement.
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