The gene CCBL1 (cysteine-S-conjugate ß-lyase) is expressed in the brain. CCBL1 belongs to aminotransferases fold type I subfamily. The protein localizes in the cytoplasm. However, it is mitochondrial in brain. CCBL1 is commonly referred to as KAT1 (kynurenine aminotransferase I).
Synonyms: Anti-CCBL1; Anti-GTK; Anti-KATI; Anti-Cysteine-S-conjugate beta-lyase; Anti-GTK; Anti-Glutamine--phenylpyruvate transaminase; Anti-KATI; Anti-Kynurenine aminotransferase I; Anti-Kynurenine--oxoglutarate transaminase 1
Storage: -20C
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Biochem Physiol Actions: CCBL1 (cysteine-S-conjugate ß-lyase) is an aminotransferase and a cysteine S-conjugate ß-lyase. It is responsible for transamination of kynurenine resulting in the formation of neuroactive compound, kynurenic acid. CCBL1 is suggested to have a role in pathogenesis of Parkinson's disease. CCBL1 activity increases in post-mortem brain samples from humans with schizophrenia.
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