Potassium sodium-activated channel subfamily T member 2 (KCNT2), also known as SLO2.1, is a Na+-activated K+ (KNa) channel. An elevation in [Na+]i activates this channel. It is composed of tetrameric complexes with each subunit having six transmembrane regions. KCNT2 is expressed in the heart and central nervous system. It belongs to the mammalian Slo potassium channel gene family. The protein indirectly responds to neuronal sensors and the gene encoding it is localized on human chromosome 1q31.3. The protein may have a role in modulating the basal level of excitability of cells and may also contribute to their resting potentials.
Synonyms: Anti-KCa4.2; Anti-SLICK; Anti-SLO2.1; Anti-potassium channel, subfamily T, member 2
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC