Glial cell line-derived neurotropic factor receptor ? 1 (GFRA1) is a member of GDNF receptor ? family (GFR?). It is encoded by the gene mapped to human chromosome 10q25.
Synonyms: Anti-GDNF family receptor alpha 1; Anti-GDNFR; Anti-GDNFRA; Anti-GFR-ALPHA-1; Anti-RET1L; Anti-RETL1; Anti-TRNR1
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Glial cell line-derived neurotropic factor receptor ?1 (GFRA1) acts as a co-receptor of tyrosine-protein kinase receptor (RET) for the growth factor GDNF (glial cell line-derived neurotropic factor). The encoded protein functions as a ligand-induced cell adhesion molecule (LICAM) to build specific synaptic contacts and stimulates presynaptic differentiation.The expression of this protein, along with GFR?3 and artemin (ARTN), might be useful in determining the prognosis of certain subsets of mammary carcinoma. Reduced expression of GFRA1 in neurons is associated with the pathogenesis of Alzheimer's disease (AD). Therefore, administration of GFR?1 with GDNF and artemin into AD neurons can be a potential therapeutic method to improve cell survival.
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