Fanconi-associated nuclease 1 (FAN1) encodes DNA repair nuclease, which is necessary for interstrand cross link DNA repair. The gene FAN1 is located on human chromosome 15q13.3.
Synonyms: KIAA1018; MTMR15
Storage: -20C
Application: Anti-FAN1 antibody recognises FAN1 protein.
Biochem Physiol Actions: Fanconi-associated nuclease 1 (FAN1) has 5' flap endonuclease and 5'-3' exonuclease activity. Mutations in FAN1 gene causes Fanconi anaemia, which is a bone marrow failure disorder, associated with chromosome fragility and vulnerability to cancer. Aberrations in FAN1 leads to improper DNA repair and causes psychiatric and neurodevelopmental disorders like schizophrenia and autism.(2) Mutations in FAN1 is linked to karyomegalic interstitial nephritis (KIN) in kidney. It is also related to hereditary colorectal cancer.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC