DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) is a highly conserved kinase, which is a member of the CMGC family of protein kinases. It is a serine/threonine kinase, which is a Drosophila minibrain gene homolog. This gene is localized to human chromosome 21, and is expressed in both nucleus and cytoplasm. It has a ubiquitous expression pattern, and shows predominant expression in hippocampus, cerebellum and olfactory bulb.
Synonyms: Anti-Dual specificity YAK1-related kinase; Anti-Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Anti-HP86; Anti-MNBH; Anti-Protein kinase minibrain homolog; Anti-hMNB
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) is involved in the homeostasis of tissues, and in human development. This gene is up-regulated in Down syndrome (DS) patients, which is linked with changes in motor functions, osteoporosis, aberrations in retina etc. Mutations resulting in truncated protein are linked to retardation in general growth and severe primary microcephaly. Mutations in this gene are also associated with deregulation of pancreatic function, and progression of tumor. This gene is down-regulated in Alzheimer's disease, and its plasma levels might be diagnostic marker for the same. It acts as a tumor suppressor in acute myeloid leukemia (AML), and its expression is suppressed in the same. It suppresses the proliferation of AML cells, by degrading c-Myc, and also influences chemoresistance in AML patients.
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