Cell adhesion molecule-related, downregulated by oncogenes (CDON) gene is mapped to human chromosome 11q23-24. The CDO protein encoded by this gene is a known cell surface receptor of the immunoglobulin superfamily This cell surface protein consists of five Ig repeats and three fibronectin type III (FNIII) repeats in its extracellular region, a transmembrane domain and a peculiar 270 amino acid intracellular region.
Synonyms: Anti-CDO; Anti-CDON1; Anti-ORCAM
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Cell adhesion molecule-related, downregulated by oncogenes (CDON) acts as a tumor suppressor gene in neuroblastomas. It acts as a high potential therapeutic target for PCa (prostate cancer). CDON functions as a receptor in SHH (sonic hedgehog) signaling pathway involved in neural crest cell fate during embryonic development. It is also known to activate apoptotic process in the absence of SHH pathway. CDO protein enhances myocardium formation of pluripotent stem cells.Nonsense mutation of CDON gene involved in SHH signaling will lead to congenital defect called as holoprosencephaly (HPE).CDO associates with co-receptor BOC (brother of CDO[cell adhesion molecule, down-regulated by oncogenes)] by mutually linking their internal domains and ectodomains. This complex is involved in the regulation of myogenic differentiation.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC