Calcium (Ca2+)/calmodulin-dependent protein kinase kinase-2 (CaMKK2) comprises unique N- and C-terminal and a central catalytic domain and is expressed in the nervous system. It belongs to the CaMK family. The CaMKK2 gene is mapped to human chromosome 12q24.31.
Synonyms: Anti-CaM-KK beta; Anti-CaM-kinase kinase beta; Anti-CaMKK beta; Anti-Calcium/calmodulin-dependent protein kinase kinase 2; Anti-Calcium/calmodulin-dependent protein kinase kinase beta
Storage: -20C
Application: Anti-CAMKK2 antibody produced in rabbit has been used in:
•western blotting
•immunohistochemistry
•immunofluorescence microscopy
Biochem Physiol Actions: Calcium (Ca2+)/calmodulin-dependent protein kinase kinase-2 (CaMKK2) has calmodulin (CaM) binding sequence and serves as an upstream kinase for histone deacetylase Sirtuin 1 (Sirt1) and AMP-activated protein kinase (AMPK). It regulates axonal growth and mediates neuronal plasticity. Single nucleotide polymorphisms in the CaMKK2 gene are implicated in schizophrenia, anxiety, and bipolar disorder. Deletion of CaMKK2 is correlated to loss of long-term memory. Elevated expression of CaMKK2 is observed in gastric, breast and ovarian cancers.
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