The gene ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) is mapped to human chromosome 2q35.
Synonyms: Anti-5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; Anti-AICAR transformylase; Anti-ATIC; Anti-Bifunctional purine biosynthesis protein PURH; Anti-IMP synthetase; Anti-Inosinicase
Storage: -20C
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Biochem Physiol Actions: ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) is a bifunctional enzyme which is important for purine biosynthesis. It exhibits folate-dependent AICAR (aminoimidazole-4-carboxamide ribonucleotide) transformylase and also IMP (inosine monophosphate) cyclohydrolase activity. Mutations in ATIC are linked with AICA (5-amino-4-imidazolecarboxamide)-ribosiduria, an inborn error of purine biosynthesis.
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