ASGR2 (asialoglycoprotein receptor 2) is one of the two subunits of the hetero-oligomeric ASGP-R, which is expressed specifically on hepatocytes. It is also called H2 and shares high homology with the other subunit called H1. ASGP-R is present on the plasma membrane of hepatocytes, towards the sinusoidal side, and undergoes endocytic recycling. This receptor is a type II membrane protein, and thus, ASGR2 has its N-terminal towards the cytoplasm, one transmembrane region, a stalk region and a Ca2+-dependent CRD (carbohydrate recognition domain). The molecular weight of this subunit is ~ 50kDa.
Synonyms: Anti-ASGP-R 2; Anti-ASGPR 2; Anti-Asialoglycoprotein receptor 2; Anti-Hepatic lectin H2
Storage: -20C
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Biochem Physiol Actions: ASGR2 (asialoglycoprotein receptor 2) forms a subunit of ASGR, which internalizes desialylated glycoproteins, and transports them to lysosomes. It is also a receptor for hepatitis B virus (HBV), the chronic infection of which can affect the male reproductive system. As ASGR is also expressed in human testis, it might be responsible for HBV infection in the luminal compartment of testis. This receptor is also involved in the immune regulation and inflammatory processes in hepatocytes, and promotes liver cell toxicity. An alternatively spliced form of ASGR2 subunit, called sH2a is found in serum of healthy individuals. The serum level of this form is changed in liver fibrosis, and defines the status of hepatocyte function. Thus, it has potential as a non-invasive marker for liver function and fibrosis.
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