Synonyms: Anti-ALK-1 antibody produced in rabbit; Anti-Activin receptor-like kinase 1 antibody produced in rabbit; Anti-SKR3 antibody produced in rabbit; Anti-Serine/threonine-protein kinase receptor R3 precursor antibody produced in rabbit; Anti-TGF-B superfamily receptor type I antibody produced in rabbit; Anti-TSR-I antibody produced in rabbit
Storage: -20C
Application: Anti-ACVRL1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: ACVRL1 (Activin A receptor type II-like 1) is an endothelial cell-specific type I receptor of the TGF-ß superfamily. It is highly expressed in the vascular endothelial cells. It mainly regulates the normal blood vessel development. It functions as a type I receptor for the BMP (bone morphogenetic protein) ligand, BMP9 and BMP10. It conjugates with the ligands to form a receptor complex with type II and type I transmembrane serine/threonine kinases. Phosphorylated type II receptors activate type I receptors for autophosphorylation. Furthermore, the activated type I receptors bind and activate SMAD signaling pathway for the transcriptional regulation. Mutation in the ALK1 gene causes a hereditary vascular disorder, hemorrhagic telangiectasia type 2 (HHT2).
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC