Synonym: 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX
CAS Number: 28822-58-4
Empirical Formula (Hill Notation): C10H14N4O2
Molecular Weight: 222.24
Beilstein Registry Number: 247859
EC Number: 249-259-3
MDL Number: MFCD00005584
PubChem Substance ID: 242776806
Packaging
1, 5 g in poly bottle; 250 mg in poly tube; 100 mg in poly bottle
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 µM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1
Assay: =99% (HPLC)
Form: powder
Color: white to off-white
MP: 200-201 °C(lit.)
Solubility: DMSO: soluble1 M (with gentle warming), ethanol: soluble10 mg/mL
Storage Temp.: -20°C
Gene Information: human ... PRKAR1A, PRKAR1AP, PRKAR1B, PRKAR2A, PRKAR2B; rat ... Adora1, Adora2a