27-hydroxycholesterol induces glutathione depletion, apoptosis, reactive oxygen species (ROS) generation and inflammation.
Synonyms: (25R)-26-Hydroxycholesterol; (25R)-Cholest-5-ene-3b,26-diol; 25®-27-hydroxy Cholesterol; 27-OHC
Molecular Formula: C27H46O2
Molecular Weight: 402.65
Linear Structural Formula: C27H46O2
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: 27-hydroxycholesterol is a peripherally derived oxysterol that that is produced by the enzyme CYP27A1. There has beeen increasing interest in the oxysterols, especially in the brain. Impairment of brain cholesterol metabolism has been associated with several neurodegenerative diseases. 27-hydroxycholesterol crosses the blood brain barrier and have been associated with Alzheimer's disease. It is an activator of LXRalpha and LXRbeta in vitro with EC50 values of 85 and 71 nM and an inhibitor of cholesterol synthesis. 27-hydroxycholesterol has also been shown to bind to estrogen receptor-alpha (ERalpha) and Erbeta, acting as an endogenous selective estrogen receptor modulator (SERM). In murine models of breast cancer 27-hydroxycholesterol significantly increased tumor growth and metastasis.