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MilliporeSigma

2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid >=95%

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2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid >=95%

Synonyms: Semi-flexible linker for PROTAC(R) development

Molecular Formula: C18H25NO4

Molecular Weight: 319.4

Linear Structural Formula: C18H25NO4

Purity: >=95%

Melting Point: 164-170 C

Storage: 2-8C

Application: 2-(4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Other Notes: Portal: Building PROTAC(R) Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

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Product Detail
Thomas No.
CHM02V363
Mfr. No.
917362-100MG
Description
917362-100MG, 2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid >=95%
CAS Number
1000991-31-0
list price/quantitytotal
$0.00
$0.00 (0 Items)
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