Primary Polyclonal

Antigen: human 15-LO-2 amino acids 161-179 Host: rabbit Cross Reactivity: (+) human 15-LO-2; (−) rabbit reticulocyte 15-LO-1 and porcine leukocyte 12-LO-1 Application(s): WB 15-LO-2 oxygenates C15 of arachidonic acid to produce 15(S)-HETE. Expression of 15-LO-2 appears to be restriced to...

Immunogen: Peptide from the C-terminal region of human TP receptor Host: Rabbit Species Reactivity: (+) human, COS-7 (African green monkey), mouse, and rat TP receptor Application(s): ICC and WB The TP receptor is a GPCR that mediates the action of TXA2.

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser778 of rat dynamin Host: sheep Cross-reactivity: (+) rat dynamin Application: WB

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr34 of rat DARPP-32 Host: rabbit Cross Reactivity: (+) rat DARPP-32 Application(s): WB DARPP-32 is a dopamine and cAMP-regulated phosphoprotein that plays a critical role in the regulation of dopaminergic...

Antigen: human CysLT1 receptor C-terminal amino acids 318-337 Host: rabbit Cross Reactivity: (+) human CysLT1 receptor Application(s): FC, ICC, IHC (paraffin-embedded sections), and WB The CysLT1 receptor binds LTD4, LTC4, and LTE4, playing a major role in asthma by facillitating airway and...

Immunogen: Synthetic peptide from the N-terminal cytoplasmic region of human protein CB1 receptor Species Reactivity: human, mouse, and rat CB1 Host: Rabbit Application(s): (+) WB This antisera has been raised against the N-terminal (amino acids 1-14) extracellular region of the of the CB1 receptor,...

Antigen: human RICK amino acids 11-30 Host: rabbit Application(s): WB Overexpression of RICK promotes the activation of caspase-8 and Fas-induced apoptosis. RICK represents a novel kinase that regulates Fas-induced apoptosis.

Antigen: Peptide from the C-terminal region of human dopamine β-hydroxylase (DBH) Host: sheep Cross Reactivity: (+) Human, mouse, and non-human primate tissue DBH Application: WB

Antigen: peptide corresponding to a portion of human LSD1 amino acids 100-150 Host: rabbit Cross Reactivity: (+) canine, human, mouse, rat, Rhesus monkey, and zebrafish LSD1 Application(s): WB LSD1 functions as a transcriptional corepressor and catalyzes the flavin-dependent demethylation of Lys4 of...

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser301 of rat Raf-1 Host: rabbit Cross Reactivity: (+) rat Raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus Raf-1 Application(s): WB Studies have shown that...

Antigen: synthetic peptide from human HDAC11 amino acids 182-199 Host: rabbit Cross Reactivity: (+) human, mouse, and rat HDAC11 Application(s): WB HDAC11 is a class IV HDAC that is expressed in kidney, heart, brain, skeletal muscle, and testis.

Antigen: rat sEH amino acids 292-306 Host: rabbit Cross Reactivity: (+) human, mouse, and rat sEH; expected to react with bovine, canine, chicken, and porcine sEH Application: WB Soluble epoxide hydrolase (sEH) metabolizes exogenous and endogenous epoxides into corresponding diols.

Antigen: a portion of the NF-κB (p65) NLS Host: rabbit Cross-reactivity: (+) bovine, chimpanzee, gorilla, equine, human, monkey, and mouse NF-κB (p65) Application(s): ICC and WB p65 is a part of the NF-κB (p50/p65) heterodimer. IκB interacts with NF-κB dimers and...

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human β-catenin Host: rabbit Cross-reactivity: (+) human β-catenin Application: WB β-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in...

The nitrotyrosine affinity sorbent consists of Cayman’s nitrotyrosine monoclonal antibody conjugated to Sepharose 4B. Application(s): IP and WB The sorbent is designed for immunoprecipitation of nitrated proteins from biological samples. This is an effective way to concentrate nitrated...

Antigen: synthetic peptides corresponding to amino acids 12-29 and 36-50 of human SMAD7 Host: rabbit Cross Reactivity: (+) human, mouse, rat, and ovine SMAD7; predicted to react with chimpanzee, canine, pufferfish, Xenopus, and zebrafish SMAD7 Application(s): WB SMAD7 is an inhibitory SMAD (I-SMAD)...

Antigen: human IGFBP5 amino acids 192-206 Host: rabbit Cross Reactivity: (+) mouse and rat IGFBP5 Application(s): WB IGFBP5 is a secreted protein that binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and...

Immunogen: Synthetic peptide from an internal region of human protein Host: rabbit Cross Reactivity: (+) human, mouse, and rat SREBP-2 Application(s): ICC and WB SREBP-2 is a transcription factor that plays a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty...

Immunogen: Synthetic peptide from the C-terminal region of human PAF-AH Host: Rabbit Species Reactivity: (+) Human PAF-AH; (−) Mouse, guinea pig, canine, and chicken PAF-AH Application(s): WB PAF-AH converts PAF to the biologically inactive lyso-PAF. Plasma PAF-AH is highly selective for...

Immunogen: Synthetic peptide from the C-terminal region of human protein Nrf2 Host: Rabbit Species Reactivity: (+) Human, mouse, and rat Nrf2 Application(s): FC, IF, and WB This C-terminal Nrf2 polyclonal antibody preferentially detects polyubiquitinated Nrf2 at 90 kDa. Nrf2 forms a heterodimer with...

Antigen: human 11β-HSD1 amino acids 78-92 (CLELGAASAHYIAGT) Host: rabbit Cross-reactivity: (+) human, mouse, and rat 11β-HSD1 Applications: IHC (formalin-fixed paraffin-embedded tissue) and WB 11β-HSD1 catalyzes the conversion of inactive cortisone to active cortisol in adipose...

Antigen: synthetic peptide from human histone H2B amino acids 111-125 Host: rabbit Cross Reactivity: (+) chicken, canine, Drosophila, human, most mammals, mouse, rat, and zebrafish histone H2B Application(s): WB Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer,...

Antigen: amino acids 234-249 of human SMAD2 Host: rabbit Cross Reactivity: (+) Bovine, canine, chicken, chimpanzee, human, mouse, and rat SMAD2 Application(s): IHC and WB SMAD2 is an intracellular protein that associates with SMAD4 for translocation to the nucleus. It acts as an intracellular...

Antigen: peptide from the N-terminal region of human GPR41 Host: rabbit Cross Reactivity: (+) human GPR41 Application(s): FC, IF, and WB