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Prostaglandin D2 (PGD2) is biosynthesized in the brain by a soluble, 26 kDa glutathione-independent lipocalin-type PGD2 synthase. This PGD2 accumulates in the cerebrospinal fluid (CSF), where it induces physiologic sleep in rats and humans. PGD2 is also synthesized in mast cells and leukocytes by a...
A dye which stains proteins in gels with ease and sensitivity; used in the Bradford to quantify the amount of protein in a solution; selectively inhibits P2X7 (IC50s = 10.1 nM and 265 nM for rat and human P2X7, respectively) and reduces neurological injury secondary to traumatic brain...
A fluorescently-labeled fructose derivative that specifically accumulates in cells bearing GLUT5 transporters and is used to monitor fructose uptake in normal and cancerous cells via fluorescent microscopy.
A trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains.
Cyclooxygenase catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid to prostaglandin H2. Recent discoveries of the induction of cyclooxygenase biosynthesis by a variety of stimuli such as phorbol esters,...
An anthranilic acid derivative that activates the oxidized (heme-free) form of sGC (EC50 = 0.5-10 µM in purified bovine lung or crude human corpus cavernosum) by binding to the heme pocket and mimicking its function; increases cGMP levels in cultured rat aorta smooth muscle cells...
A potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively); minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2; blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells.
7-hydroxy Methotrexate (7-hydroxy MTX) is the major metabolite of the folic acid derivative MTX (Item No. 13960).{34769} It is formed by the 7-oxidation of MTX by hepatic aldehyde oxidases. Unlike MTX, 7-hydroxy MTX does not inhibit thymidylate synthase in isolated human acute myeloid and acute...
A cell-permeant precursor of the fluorescent calcium indicator fura-FF, which has negligible magnesium sensitivity and a higher calcium dissociation constant than fura-2 (Kd(calcium) = 5.5 and 0.14 µM, respectively).
A synthetic intermediate useful for pharmaceutical synthesis.
A cell-permeable, cyclic nucleotide derivative that mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.
A trypsin-like proteasome inhibitor (IC50 = 1 nM) that deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually...
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARβ. INDIGO’s reporter cells...
Formal Name: 5-[(1S,3aR,4R,6aR)-4-(1,3-benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole CAS Number: 526-07-8 Molecular Formula: C20H18O7 Formula Weight: 370.4 Purity: ≥98% Formulation: A crystalline solid
A metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase; enhances utilization by anion transporters, most commonly leading to excretion in urine and bile.
An inhibitor of RSKs.
An inverse agonist of PPARγ (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of FABP4 in differentiating murine preadipocytes; promotes osteogenesis in cultured human MSCs.
A sensitive fluorogenic elastase substrate that is selectively cleaved by elastase to yield Rhodamine 110, which can be analyzed with an excitation wavelength of 485 nm and emission wavelength of 525 nm.
Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Ideally suited for use as an internal standard in mass spectrometry applications The deuterated primary prostaglandin metabolite LC-MS mixture...
A selective RARγ agonist (Kds = 150, 1,500, and 2,750 nM for RARγ, RARβ, and RARα receptors, respectively); demonstrates transcriptional activity at RARγ with an AC50 value of 1.8 nM.
Leelamine is a diterpene molecule whose name derives from the Sanskrit word leela which means "play". It has weak affinity for the human CB1 and CB2 receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.{14127} Leelamine inhibits pyruvate dehydrogenase...
A uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules, which is a key mechanism targeted in the treatment of gout; inhibits degranulation of platelets, reducing the release of ADP and thromboxane and diminishing platelet aggregation.
A potent, selective antagonist of the GPR55 receptor (IC50 = 221 nM).
4-ONE-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-ONE by GC- or LC-MS.