Cayman Chemical

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC₅₀s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively). It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in...

A selective CRF1 antagonist (Ki = 4 nM); inhibits cAMP accumulation and ACTH production in vitro (pIC₅₀s = 7.1 and 6.9, respectively) and reduces CRF- and stress-induced ACTH production in vivo.

A modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA; used to quantify DNA hydroxymethylation levels in biological samples.

A certified reference material categorized as a phytocannabinoid; has been found in a Cannabis variety grown for medicinal purposes; intended for research and forensic applications

A natural, nicotine-related alkaloid that binds the same receptor as nicotine, the nicotinic acetylcholine α4β2 subtype (Ki = 38 nM) and increases nicotine-induced hyperactivity, sensitization, and intravenous self-administration.

An AHL autoinducer that promotes the expression of the transcriptional activator (and LuxR homolog) TraR.

A macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM); also acts as an endothelin receptor antagonist and has antiosteoporotic activities.

A potent CXCR7 receptor agonist.

A polyunsaturated fatty alcohol produced by the reduction of linoleic acid.

A benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.

An internal standard for the quantification of 13,14-dihydro-15-keto PGE2 by GC- or LC-MS.

A non-hydrolyzable phosphorothioate analog of cAMP that competitively inhibits cAMP-dependent protein kinases (PKA) I and II (IC₅₀s = 12.5 and 4.5 µM, respectively); broadly used in research involving cAMP-dependent signaling in vitro and in vivo.

An activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases; permits phosphorylation and activation of all isoforms of Akt in multiple cell types.

Antigen: fusion protein from the N-terminus of the δ-subunit of rat GABAA receptor Host: rabbit Cross Reactivity: (+) mouse and rat GABAA Receptor Application(s): IHC, IP, and WB GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are...

Urea is the final degradation product of protein and amino acid metabolism. Urea is found in blood and is excreted by the kidney as a component of urine. Besides its role as carrier of waste nitrogen, urea also plays a role in the countercurrent exchange system of the nephrons, allowing for...

An 18-carbon saturated fatty acid that is structurally similar to the phospholipid-derived N-acyl ethanolamines; inhibits heat-induced firing of nociceptive neurons in rat dorsal horn; induces transient calcium influx in native dorsal root ganglion (DRG) cells and in the PTX-sensitive, DRG-like cell...

A second messenger produced by bacteria that regulates chemotaxis, colonization, and other bacterial functions; triggers the expression of interferon genes in mammalian cells.

A labeled analog of AEA that is non-fluorescent when outside the cell but upon transport into the cell, is cleaved by esterases to give a bright fluorescence at 530 nm; used as an alternative substrate to study AEA transport via the AEA transporter.

A chiral auxiliary for asymmetric ketone reduction, in particular 15-keto PG intermediates to 15(S)-alcohols.

A synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 vs. 17 nM, respectively); has anti-inflammatory effects.

A primary metabolite of nicotinamide produced by the action of NNMT; demonstrates antithrombotic and anti-inflammatory properties and may play a role in cancer cell metabolism.

A potent, competitive inhibitor of HO activity in vitro (Ki = 14 nM); inhibits hepatic, renal, and splenic HO activity in vivo for extended periods of time; blocks bilirubin production in vivo, decreasing HO activity in animal models of hyperbilirubinemia.

The major eicosanoid product of mast cells released in large quantities during allergic and asthmatic anaphylaxis; also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace where it induces normal physiological sleep and lowering of...

An IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC₅₀ = ~250 nM) and subsequent NF-κB p65 nuclear translocation; exhibits cardioprotective and anti-cancer properties.