Cayman Chemical

A tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen; interacts with α5β1 and αVβ3 integrins, blocking the attachment of cells to fibronectin-coated surfaces (Ki = 0.6 mM); inhibits adhesion of platelets to...

An inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM.

Zileuton (Zyflo™) is a reversible 5-LO inhibitor that was approved in 1997 for the prevention and treatment of asthma in the USA, but was withdrawn by Abbott Laboratories in 2003. Zileuton inhibits 5-LO from rat basophilic leukemia-1 (RBL-1) cells with an IC50 value of 0.5 µM. It is a...

Antigen: synthetic peptide containing phosphorylated serine residues corresponding to human IκBα amino acids 32 and 36 Host: mouse, clone 39A1413 Isotype: IgG1κ Cross Reactivity: (+) bovine, canine, human, mouse, porcine, and rat IκBα Application(s): WB and IP External...

Antigen: a portion of amino acids 150-200 of human NF-κB (p50) Host: mouse, clone 2J10D7 Isotype: IgG1κ Cross-Reactivity: (+) human NF-κB (p50) Application(s): IHC and WB NF-κB1 (p50) is a 50 kDa functional sub-unit of NF-κB that forms homodimers or heterodimerizes with...

A natural flavanol with potent antioxidant activity.

A DHA-derived resolvin that stimulates the phagocytosis of E. coli by human macrophages.

Calcitriol is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly...

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For...

A synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM) cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM); prevents the degradation of IκBα and IκBβ by the ubiquitin-proteasome...

A PPARβ/δ antagonist.

A broad-spectrum dithiolopyrrolone antibiotic; inhibits tumor angiogenesis, blocking activity of integrin αvβ3, (IC₅₀ = 1.1 µM).

Small molecule inhibitors of sEH may hold promise as therapeutics for the treatment of hypertension and vascular inflammation. Cayman’s fluorescence-based sEH Inhibitor Screening Assay provides a convenient method for screening epoxide hydrolase inhibitors. The assay utilizes...

Each vial contains nNOS (rat) to be used as a standard for WB and electrophoresis. The enzyme has been carefully purified to exclude all unrelated proteins; may not be catalytically active.

A naturally occurring phospholipid produced by cells upon inflammatory stimulation; less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration.

An activator of the P2X receptors that exhibits 5-30-fold greater potency at the P2X7 receptor than ATP; activates the human, rat, and mouse receptors with EC₅₀ values of 0.7, 3.6, and 285 μM, respectively.

Antigen: recombinant full-length human caspase-3 Host: mouse, clone 31A1067 Isotype: IgG1κ Cross Reactivity: (+) human, mouse, and rat caspase-3 Application(s): IHC (frozen and paraffin-embedded sections) and WB Caspase-3 cleaves the death substrate PARP to a specific 85 kDa form observed...

Antigen: human COX-2 amino acids 578-596 Host: goat Cross-Reactivity: (+) human, ovine, mouse, rat COX-2; (−) COX-1 (all species) Application(s): WB, ICC, and IHC (formalin-fixed paraffin-embedded sections) Expression of COX-2, the inducible form of COX, is regulated by growth factor tumors,...

Antigen: hamster brain SAF Host: mouse, clone SAF 84 Isotype: IgG Application(s): IHC and WB

An antifungal compound clinically used to treat nail and skin infections; inhibits ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C. albicans); induces cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human vascular endothelial cells.

An internal standard for the quantification of TDGA by GC- or LC-MS.

An EpEDE acid formed from DGLA, either by a strong oxidizing agent or by cytochrome P450 epoxygenases; biological properties are poorly understood.

An inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53; binds to p53 with an apparent Kd value of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation, and activation.

A broad-spectrum pleuromutilin antibiotic that binds to peptidyl transferase in the 50S ribosomal subunit.