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A cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity (IC50 = 70 nM).
A cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM); blocks glucagon-induced hepatic glycogenolysis in vivo.
A methyl ester version of 17(R)-RvD1 which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.
An endogenous ceramide, generated by ceramide synthase 6, that acts a lipid second messenger to regulate apoptosis and stress signaling.
A CDK inhibitor that most potently inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdc2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively); inhibits the growth of parasites, including Plasmodium, at micromolar doses.
An abundant oligosaccharide in the milk of many mammals, including cows and humans, particularly postpartum; avidly binds several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus, in some cases altering viral infectivity.
A polyphenolic anthocyanin with high antioxidant activity, protecting erythrocytes from apoptosis; impairs growth and induces apoptosis in the highly tumorigenic RE-149 DHD cell line; inhibits a range of mammalian and bacterial proteases, including neutrophil elastase, MMP-1, and MMP-9.
A triazolothiadiazine that inhibits PDE4 (EC50 = 18.7 nM in a cell-based assay); selectively inhibits PDE4A (IC50 = 6.7 nM) over PDE4B1, PDE4B2, PDE4C1, and PDE4D2 (IC50 = 48.2, 37.2, 452, and 49.2 nM, respectively).
A naturally occuring deaminated sialic acid that is thought to be a precursor for the biosynthesis of other members of the sialic acid family; can be used to analyze nonulosonic acid residues in polysialoglycoproteins.
A synthetic peptide that blocks PKC activity in HepG2 cells stimulated with calcium and diacylglycerol when applied at 10 µM.
Source: Active recombinant N-terminal His-tagged enzyme amino acids 101-399 purified from E. coli Mr: 37 kDa (theoretical); 33.5 kDa (observed) SIRT3, is a mitochondrial protein that is synthesized as an enzymatically inactive protein. Human SIRT3 is activated by a matrix-processing peptidase. The...
A natural bacterial product that activates GPR132 (also known as G2A) with an EC50 value of 11.8 µM.
An indole-based, time-dependent inhibitor of Icmt (IC50 = i = 0.14 µM for the final complex); decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells.
An isotopically enriched form of a PUFA standard with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.
An inactive enantiomer of nutlin-3 that may serve as a useful control for non-MDM2 related cellular activities; also called enantiomer b based on the elution pattern during chiral separation of (±)-nutlin-3.
Mn(III)TMPyP is a cell-permeable SOD mimic and peroxynitrite decomposition catalyst. The rate constants for superoxide dismutation and peroxynitrite decomposition are 3.9 x 107 M−1s−1 and ~2 x 106 M−1s−1, respectively.
Inhibits Gli1-mediated transcription (EC50 = 5 μM) in a variety of cell types disrupting the hh signaling pathway downstream of Smo and Sufu; displays antiproliferative and antitumor activity against Ewing sarcoma family of tumor cells.
A potent, reversible 5-LO inhibitor, blocking LTB4 synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes; also attenuates LTB4 synthesis, prevents carrageenan-induced pleurisy, and protects against PAF-induced shock in mice when given intraperitoneally.
L-Biopterin is the oxidized form of BH4, a NOS cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs). L-Biopterin is rarely found...
A potent, selective inhibitor of TrkA (IC50 = 2 nM); used to clarify the role of TrkA in regulating cell function.
A hydrophobic bile acid formed in the liver by conjugation of lithocholate with taurine; induces apoptosis in hepatocytes at 75 µM; used to experimentally induce cholestasis.
A degradation product of the surfactant, Triton X that produces weak estrogenic effects in animal and human research studies.
This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human liver X receptor alpha (NR1H3), a ligand-dependent transcription factor commonly referred to as LXRα. INDIGO’s reporter cells include the...
Ascorbate (L-Ascorbic acid or Vitamin C) is a six-carbon lactone that is synthesized from glucose in the liver of most mammalian species, but not by humans who must obtain ascorbate through dietary consumption. In humans, ascorbate serves as an antioxidant and acts as an electron donor for various...