Cayman Chemical

An ATP-competitive Pim-1 kinase inhibitor (IC₅₀ = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC₅₀s = >20 µM).

An antiproliferative agent that presumably modulates xenobiotic-metabolizing enzymes, such as inhibiting CYP450, and/or induces phase II detoxifying enzymes.

Curcumin is an extract of turmeric root with antioxidant, anti-tumor, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages.

Antigen: recombinant mouse L-PGDS Host: rabbit Cross-reactivity: (+) human and mouse L-PGDS Applications: WB and IHC

A plant alkaloid that demonstrates cytotoxicity against leukemia P-388 cells (IC₅₀ = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex.

Inhibits HDAC activity much more potently (IC₅₀ = 13 µM) than valproic acid (IC₅₀ = 398 µM); induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM; induces the expression of Hsp70-1a and Hsp70-1b and protects cerebellar granule...

A synthetic intermediate useful for pharmaceutical synthesis.

A fluorinated antibiotic related to chloramphenicol and thiamphenicol, used primarily in veterinary medicine.

A cell-permeable, reversible inhibitor of HDACs (IC50 = 30 nM).

An intermediate product in the synthetic pathway of biopterin that is released from macrophages upon immune stimulation with interferon-γ from activated T cells; routinely used as a biochemical tool to screen for and monitor the progression of certain diseases accompanied by hyperimmune...

An AT1 receptor antagonist (Ki = 5-20 nM); attenuates vein graft atherosclerosis in rabbits and reduces arterial blood pressure in rats; controls hypertension while protecting renal function, in humans.

Antigen: His-tag recombinant mouse Dnmt3a expressed in bacteria Isotype: IgG1 Host: mouse, clone 64B814.1 Cross Reactivity: (+) human and mouse DNMT3a Application(s): ELISA The DNMT3 family members DNMT3a and DNMT3b are strongly expressed in embryonic stem cells. Their expression is down regulated...

A hybrid molecule of an H2S donor and the NSAID diclofenac that does not cause gastric damage or promote leukocyte adherence to vascular endothelium; exhibits efficacy at doses of 10-50 µmole/kg in rat.

A reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9 with preference towards MMP-2 (IC50 = 4 and 20 µM, respectively).

A panaxatriol that has diverse in vitro and in vivo effects, including neuroprotective, pro-angiogenesis, anti-inflammatory, and hypertensive actions in clinical trials.

A major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization; used as a biomarker to assess endogenous production of PGD2.

A natural catechin which inhibits the growth of cancer cells and has anti-inflammatory effects; has potent antioxidant activity and facilitates the killing of methicillin-resistant strains of S. aureus.

A potent inhibitor of enkephalin convertase (Ki = 8.8 nM) that is functional in vivo; can also inhibit other carboxypeptidases, including TAFI.

A type B trichothecene mycotoxin found in cereals contaminated with certain Fusarium species.

A topoisomerase I inhibitor that is cytotoxic to HT-29 cells (IC₅₀ = 19 nM), induces DNA damage in whole cells (at 85 nM), and demonstrates significant anti-tumor activity.

A streptogramin antibiotic that is usually combined with another streptogramin antibiotic, dalfopristin, to synergistically kill Gram-positive bacteria.

Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. Bicyclo PGE1 is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. 13,14-dihydro-15-keto PGE1 itself is a...

Antigen: murine COX-1 amino acids 274-288 Host: rabbit Cross-Reactivity: (+) mouse and rat COX-1; (−) human and ovine COX-1, COX-2 (all species) Application(s): WB and IHC

Source: recombinant N-terminal His-tagged protein expressed in E. coli MW: 19 kDa