Cayman Chemical

A cell-permeable inhibitor of JMJD2E (KDM4DL; IC₅₀ = 920 nM); reduces the expression of immediate early genes of HSV (IC₅₀ = ~10 µM) and hCMV, blocks viral infection, and suppresses the level of viral reactivation in a ganglia explant model of latently infected mice.

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

An inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM; associates with the p97-associated deubiquitinating complex in cells, preventing deubiquitination of substrates by ataxin-3; interferes with both retrograde and anterograde trafficking of...

A hydrophobic peptide chemosensitizer that reverses P-glycoprotein-mediated multidrug resistance; binds to the P-glycoprotein multidrug transporter (MDR1; Kd = 77 nM).

Mammalian sEH is a member of the α/β-hydrolase fold family of enzymes that catalyze the hydrolysis of exogenous and endogenous epoxides to vicinal diols. Endogenous substrates for sEH include EETs which exhibit vasodilatory and anti-inflammatory activity. Cayman’s sEH Cell-Based...

Peptide Sequence: murine COX-2 amino acids 570-598 (DPQPTKTATINASASHSRLDDINPTVLIK) To be used in conjunction with Cayman’s COX-2 (mouse) polyclonal antibodies (Item Nos. 160106, 160116, or 160126) to block protein-antibody complex formation during analysis for COX-2.

Antigen: synthetic peptide corresponding to human NF-κB (p65) amino acids 2-17 Host: rabbit Cross-Reactivity: (+) chimpanzee, human, and monkey NF-κB (p65) Application(s): WB The active nuclear form of the NF-κB transcription factor complex is composed of two DNA binding subunits,...

Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Designed for direct snap and inject use in mass spectrometry applications Ideally suited for method development and as a system suitability...

A modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM).

Antigen: full length recombinant human HMGB1 Host: mouse, clone IMG19N10B7 Isotype: IgG2b? Cross Reactivity: (+) human and mouse HMGB1 Applications: FC, IHC (paraffin-embedded tissue), and WB HMGB1 is a necessary and sufficient mediator of inflammation during sterile and infection-associated...

An orally bioavailable inhibitor of Smo; blocks binding of BODIPY cyclopamine (IC₅₀ = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC₅₀s = 6-35 nM); inhibits Shh pathway activity and prevents tumor growth in...

Source: recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1). Mr: 12.4 kDa

A minor impurity produced in the synthesis of (+)-cloprostenol; 20-fold less active than (+)-cloprostenol in terminating pregnancy in the hamster.

A homolog of DHEA, characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon.

A prodrug for terbutaline, a long-acting β-adrenoceptor agonist (Ki = 15.4 µM for human β2-adrenergic receptor); converted to terbutaline by butyrylcholinesterases in the liver and plasma.

11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated...

A selective antagonist of NMDA receptors containing the NR2A subunit (pIC₅₀s = 6.8 and<4.3 for human recombinant nr2a and nr2b, respectively); binds to a novel allosteric site located at the dimer interface between the glun1 and glun2 binding domains, thereby reducing glycine signal...<>

A selective, non-imidazole histamine H3R antagonist with high affinity at the rat (pKi = 8.9) and human (pKi = 9.24) H3 receptors.

An organic disulfide that inhibits TGM2 with an IC₅₀ value of approximately 2.5 mM; neuroprotective in mouse models of Huntington’s disease; also inhibits caspase 3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.

A selective ALK inhibitor that blocks the proliferation of ALCL-derived and ALK-dependent cell lines (IC₅₀s = 2-5 nM); suppresses tumor growth in in vivo models of ALK-positive ALCL and neuroblastoma; also inhibits the activity of the Parkinson’s disease-linked LRRK2...

A CB1 receptor ligand with less potency than R-1 methanandamide; inhibits electrically evoked contractions in isolated murine vas deferens (IC₅₀ = 230 nM); binding affinity for CB1 receptors is less than that of AEA (Ki = 175 nM for the displacement of radiolabeled CP 55,940).

A TZD derivative that inhibits 15-PGDH activity with an IC₅₀ value of 31 nM.

Racemic version of a CYP450 and epoxide hydrolase metabolite of arachidonic acid.