Cayman Chemical

A bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium; inhibits mycolic acid biosynthesis (Ki = 2 nM).

Host: mouse, clone 18F6 Isotype: IgG1κ Application(s): ELISA and WB

Glucose-6-phosphate dehydrogenase (G6PDH) is a cytosolic enzyme that catalyzes the first step in the pentose phosphate pathway. This pathway includes converting glucose to ribose-5-phosphate, a precursor to RNA, DNA, ATP, CoA, NAD, and FAD. The pathway also generates NADPH. G6PDH deficiency, the...

A quinazolinone derivative that selectively inhibits dynamin GTPase activity in yeast and mammalian cells (IC₅₀ = 1-10 μM); prevents apoptosis by inhibiting mitochondrial outer membrane permeabilization.

A chalconoid with anti-inflammatory and anti-tumor activity; suppresses NO and PGE2 synthesis, COX-2 expression, and NF-κB signaling; induces apoptosis in cancer cells.

A prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling; may activate TRPV1 and TRPV4.

A selective COX-2 inhibitor that exhibits IC50 values of 26.1 and 0.87 µM for COX-1 and COX-2, respectively, in a human whole blood assay.

An an antimicrobial agent that is often used in antiseptics and dental products such as toothpaste and mouthwash; inhibits MMP-2, -8, and -9.

Primes embryonic stem cells for differentiation (EC₅₀ = 0.3 μM) in lineage specification stimulus cues by inhibiting the nuclear localization of NME2 and down-regulating c-Myc expression.

BW 245C is a selective agonist for the DP1 receptor. The Ki of BW 245C for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM. It has a reported IC50 of 2.5 nM for the inhibition of ADP-induced human platelet aggregation and an IC50 of 250 nM for the inhibition of rat...

Antigen: mouse COX-2 amino acids 584-598 Host: rabbit Cross-Reactivity: (+) human, macaque monkey, mouse, ovine, and rat COX-2; (−) COX-1 (all species); expected to react with bovine and canine COX-2 Application(s): IHC (formalin-fixed paraffin-embedded tissue) and WB

A steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors; also is the precursor to aldosterone synthesis.

A glycine conjugate of lithocholic acid, a bile acid.

Stearidonic acid is an 18-carbon, ω-3 fatty acid which is a dietary precursor to EPA and DHA. Stearidonic acid is present in small amounts in seed oils, especially black currant seed oil.

Source: Human recombinant PP2A catalytic subunit expressed in insect cells with an N-terminal octahistidine-tag followed by a streptactin-tag. The C-terminal leucine 309 was deleted. MW: 38.6 kDa PP2A is a divalent cation-independent protein serine/threonine phosphatase involved in regulating...

A selective and potent ROCK inhibitor (IC₅₀ = 11.8 nM for ROCK-II); poorly inhibits CaMKII, protein kinase G, and Aurora A (IC₅₀ = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC₅₀ ≥ 10 μM for each).

A natural coumarin that increases cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling; exhibits vasorelaxant, immunomodulatory, antioxidative, and anti-inflammatory properties.

A metabolite of vitamin A that acts as a ligand for both the RAR and the RXR.

A site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.

A certified reference material categorized as a phytocannabinoid; has been found in Cannabis; intended for research and forensic applications

A lipid peroxidation product derived from oxidized ω-6 PUFAs such as linoleic acid and arachidonic acid which is widely used as a marker of lipid peroxidation.

A selective GIRK1/2 activator (EC₅₀s = 0.16 and 1.8 μM for GIRK1/2 and GIRK1/4, respectively; 60 mg/kg can delay seizure onset and prevent convulsions in two different mouse models of epilepsy.

A reagent used to detect singlet oxygen generation; can be photobleached by singlet oxygen to its corresponding endoperoxide.

PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis. Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-.DELTA.12,14-PGJ2, and NSAIDS. BADGE...