Select up to 3 products
A dual inhibitor of c-Src and Abl (IC50 = 2.7 and 30 nM, respectively); less effectively inhibits other kinases; blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival; reduces osteoclast bone resorption.
An irreversible tripeptide inhibitor of all caspases; useful in studies involving recombinant, isolated, or purified enzymes.
This nuclear receptor assay system utilizes a proprietary rodent cell line that is further engineered to express the mouse/rat peroxisome proliferator-activated receptor gamma (NR1C3, PPARG). Because the receptor’s ligand binding domain sequence is conserved between mouse and rat species, the...
Reversible, selective inhibitor of cPLA2 with an IC50 value of 4.2 nM in enzyme assays; potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively).
11-deoxy PGE2 is a stable, synthetic analog of PGE2. In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and is 5 to 30 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.
Precursor of PEA, an endogenous CB found in brain, liver, and other mammalian tissues; PEA has potent anti-inflammatory activity in vivo.
A common C-12 saturated far plentiful in coconut and other nut oils.
An analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications
2-fluoro Palmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC50 value of 0.2 mM.
A carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM) that suppresses high glucose-induced proliferation of vascular smooth muscle cells as well as prevents high glucose-induced intracellular NADH/NAD+ increase and membrane-bound protein kinase C activation.
N-2PIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM, respectively. It is over 400 times less potent as an inhibitor of...
C-8 ceramide is a cell-permeable analog of naturally occurring ceramides. Unlike C-2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels. For this reason, treatment of cells with C-8 ceramide may more closely mimic the...
A time-dependent, non-specific COX inhibitor with IC50 values of 1.5 and 9.7 µM for human recombinant COX-1 and COX-2, respectively.
An AEA transport inhibitor with essentially no activity on the CB1 receptor, CB2 receptor, or TRPV1; inhibits FAAH and MAGL and may act as an alternative FAAH substrate; inhibits glutamergic synaptic transmission between hippocampal neurons at a concentration of 3 µM.
A dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity; selectively inhibits adenosine A3 receptors (Ki = 3.25 µM) and CYP3A4 catalytic activity (IC50 = 0.148 µM); activates TRPA1 channels, producing an increase in Ca2+...
An affinity probe which allows 8-iso PGA2 to be detected through an interaction with the biotin ligand.
Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in...
A selective antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM; reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1...
Non-denaturing detergent used to solubilize and reconstitute membrane-bound proteins; characterized by a high critical micelle concentration (0.7%) which facilitates ready removal from final protein extracts.
A fluorescent calcium indicator that displays a low affinity for calcium (Kd = 42 µM).
A selective, cell-active inhibitor of NOX1 that blocks the generation of ROS in HT-29 cells (IC50 = 0.129 µM); abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM).
A DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA; significantly reduces both basal and maximal respiration in leukemia cells.
An orally bioavailable Smac/DIABLO mimetic and antagonist of IAPs (Kis = 66.4, 1.9, and 5.1 nM for XIAP, cIAP1, and cIAP2, respectively); inhibits cancer cell growth in various human cancer cell lines and induces apoptosis in xenograft tumors in mice.
A synthetic analog of curcumin that activates enzymes which catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway; increases NQO1 activity, glutathione reductase activity, and total glutathione levels in vitro at 0.6 – 0.15 μM; causes G2/M cell cycle arrest and...