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Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring. DES...
Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser9 of GSK3β Host: rabbit Cross Reactivity: (+) rat GSK3β; expected to react with human, bovine, canine, chicken, mouse, non-human primate, Xenopus, and zebrafish GSK3β Application(s): WB GSK3 is a...
An analog of AEA with no intrinsic binding affinity for either CB1 or CB2 receptors; potently inhibits AEA reuptake in U937 lymphoma cells (IC50 = 3 µM); may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations.
A Cdk2 inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H; induces cell-cycle arrest at the G2-M phase.
An antibiotic that inhibits complex III of the mitochondrial ETC, preventing electron transport between cytochromes b and c, which results in the production of superoxide and eventual cell death; inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis.
A reactive methionine analog that contains an alkyne moiety that is readily inserted into newly-synthesized proteins; can be labeled or captured through click chemistry.
A potent inhibitor of Aurora A (IC50 = 0.064 nM) that less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively); blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types; effective in vivo.
An agonist of KCNQ channels, doubling channel currents when applied at 10 µM; serves as a centrally-acting analgesic with muscle tone-reducing activity.
An endogenous mGluR2 and mGluR3 agonist implicated in the pathophysiology of schizophrenia; induces gametogenesis of P. falciparum.
A potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively); efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.
A small molecule inhibitor of nucleophosmin dimers that can prevent cell proliferation and induce apoptosis in various cancer cell lines (IC50s = 1.4-4 µM).
A cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.
An inhibitor of NF-κB activation with an IC50 value of 11 nM in human Jurkat cells; inhibits TNF-α production from LPS-stimulated mouse splenocytes (IC50 = 7 nM).
A naturally occurring plant sterol that inhibits the absorption of dietary and endogenously produced cholesterol from the small intestine, reducing blood cholesterol concentrations at 0.1 - 100 μM; dose dependently induces adipogenesis and lipolysis in rat primary preadipocytes; stimulates...
A synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells; blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS...
A nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.
Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Item No. 70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond.{22572} This bond is rapidly cleaved by bacteria in the terminal ileum and colon, releasing the active anti-inflammatory...
A mixture of trans (3R/7R and 3S/7S) isomers; induces the synthesis of proteinase inhibitors in plant leaves; in cancer cells, suppresses proliferation and induces apoptosis; inhibits hexokinase that is bound to mitochondria; methyl jasmonate derivatives also have potential as anti-inflammatory...
A cell-impermeant fluorescent calcium indicator that is characterized by high quantum yield and low phototoxicity.
A veterinary fluoroquinolone antimicrobial agent that inhibits bacterial DNA gyrase.
A potent and selective inhibitor of CK2 with an IC50 value of 0.3 µM and a Ki value of 0.2 µM.
A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively; less effectively inhibits NHE4 (IC50 ≥10 μM).
Antigen: HeLa cells transfected with human BLT1 Host: mouse, clone 7B1 Cross-Reactivity: (+) human BLT1 receptor; (−) BLT2, CysLT1, and CysLT2 receptors Application(s): FC,ICC, and IHC of frozen sections The human BLT1 receptor is a GPCR that mediates the proinflammatory effects of leukotriene...
A tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.