Cayman Chemical

Antigen: recombinant mouse His-tagged DNMT3a expressed in bacteria Host: mouse, clone 64B814.1 Isotype: IgG1κ Cross Reactivity: (+) human and mouse DNMT3a Application(s): WB, IF, and ICC The DNMT3 family members DNMT3a and DNMT3b are strongly expressed in embryonic stem cells. Their expression...

Guanfacine is an a2-adrenergic receptor (a2-AR) agonist with Ki values of 93, 1,380, and 3,890 nM for a2A-, a2B-, and a2C-ARs, respectively, in a radioligand binding assay.{40326} It has EC50 values of 52, 288, and 602 nM for a2A-, a2B-, and a2C-ARs, respectively, for stimulated [35S]GTP?S binding....

A structural analog of sphingosine that is phosphorylated in vivo to form fingolimod-phosphate, which functions as an agonist at S1P1, S1P4, and S1P5 receptors (EC50 = ~0.3-0.6 nM) and at 10-fold higher concentrations at S1P3 receptors (EC50 = ~3 nM); orally bioavailable compound with efficacy in...

A reversible inhibitor of cysteine, serine, and threonine proteases; inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.

A form of palmitic acid with an ω-terminal alkyne for use in click chemistry to isolate palmitoylated proteins.

A trichothecene mycotoxin that can be converted to DON in the body.

An internal standard for the quantification of (±)5(6)-EET by GC- or LC-MS.

A non-sedating ophthalmic antihistamine that antagonizes histamine H1 receptors (IC₅₀ = 1.58 nM) and prevents the release of pro-inflammatory mediators from mast cells and eosinophils.

An ATR inhibitor (IC₅₀ = 25 nM) that also inhibits mTOR and DNA-PK (IC₅₀s = 0.6 and 36 nM, respectively); generates replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks.

A cell-permeant low affinity calcium indicator (Kd = ~7 uM) that exhibits a shift in excitation maximum from about 480 nm to 400 nm upon binding calcium, enabling ratiometric calcium measurements.

A potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC₅₀ = 38 nM), while up-regulating the expression of Hsp70 and Hsp27; cytotoxic to cancer cells and, when administered orally to mice, inhibits growth of xenograft...

A natural product with antioxidant, anti-tumor, and anti-inflammatory properties.

Heteroatom-substituted fatty acids have been observed to modulate the extension and desaturating of fatty acids, and to influence their distribution within phospholipids pools. 10-Thiastearic acid inhibits desaturation of radiolabeled stearate to oleate in rat hepatocytes and hepatoma cells by more...

Source: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli Mr: 18 kDa

A PPARγ agonist (Ki = 19 nM; EC₅₀ = 73 nM) that was first isolated from A. fruticosa; 100 mg/kg/day improves insulin sensitivity, glucose tolerance, and plasma lipid concentrations after two weeks of treatment in insulin-resistant mice.

An atypical antipsychotic that antagonizes both central serotonin 5-HT2A (Ki = 0.42 nM) and dopamine D2 (Ki = 4.8 nM) receptors; also a potent agonist at serotonin 5-HT1A receptors (Ki = 3.4 nM) and an inverse agonist at 5-HT1B and 5-HT1D receptors (pKis = 8.8 and 8.6, respectively).

8-iso PGF1α-d9 contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8-iso PGF1α by GC- or LC-MS.

A potent inhibitor of tubulin polymerization with strong inhibitory activity on tumor cell growth.

An AMP derivative used as tool for studying adenosine-based cell regulation.

3-Pyrimidin-2-yl-Propionic Acid is a synthetic intermediate useful for pharmaceutical synthesis.

An anticonvulsant and mood stabilizing compound that inhibit both voltage-dependent sodium and voltage-dependent calcium channels, while potentiating voltage-dependent potassium channels; also antagonizes adenosine A1 receptors, stimulates dopaminergic transmission, and inhibits glutamate release.

An agonist of the bile acid receptor TGR5 (EC50 = 1 µM) and blocks fatty liver development in cells and mice given ethanol; reduces NF-κB signaling and expression of miR-33 in LPS-treated macrophages, increasing levels of ABCA1; inhibits replication of HIV-1 (IC50 = 1.4 µM) and has...

An H2S donor commonly used in cellular and whole animal experimental systems.

5-Bromotetralone is a synthetic intermediate useful for pharmaceutical synthesis.