LKT Labs
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2-n-Butylthiophene
LKT Labs2-n-Butylthiophene is a sulfur analog of furan originally found in cooked meat products. 2-n-Butylthiophene is a phase II enzyme inducer that exhibits antioxidative and chemopreventive activities. This compound increases levels of glutathione and glutathione-S-transferase, preventing…
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Cefoperazone Acid
LKT LabsCefoperazone is a third generation β-lactam cephalosporin antibiotic. Cefoperazone exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefoperazone also…
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Aflatoxin B2
LKT LabsAflatoxins are mycotoxins found in foods and livestock feeds that were initially produced by species of Aspergillus. Aflatoxin B2 is cytotoxic; it inhibits DNA synthesis and induces cell cycle arrest.
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Aceclofenac
LKT LabsAceclofenac is a diclofenac analog that exhibits anti-inflammatory and analgesic activities. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that somewhat selectively inhibits COX-2; it is clinically used to treat rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.…
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Anabaenopeptin 872
LKT LabsAnabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs). Anabaenopeptins may also inhibit carboxypeptidases.…
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Azithromycin Dihydrate
LKT LabsAzithromycin is an azalide macrolide antibiotic derived from erythromycin. Azithromycin binds the bacterial 50S ribosomal subunit, inhibiting protein translation. Azithromycin displays antibacterial, anti-fibrotic, and anti-inflammatory activities. In epithelial cells, azithromycin inhibits the…
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6-Aminonicotinamide
LKT Labs6-Aminonicotinamide inhibits glucose-6-phosphate dehydrogenase and suppresses activity in the pentose phosphate pathway. This compound exhibits potential anticancer benefit, inducing apoptosis and inhibiting the growth of cancer cells when combined with 2-deoxy-D-glucose. In vitro,…
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Ciclopirox Olamine
LKT LabsCiclopirox is a hydroxypyridone compound that exhibits antifungal, anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. This compound acts as a metal ion chelator, preventing peroxide degradation. Ciclopirox modulates generation of ROS in a PKA/Ras1/Ras2-dependent manner,…
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ß-Amyloid Peptide (1-42), rat
LKT LabsAmyloid-ß (Aß) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer’s disease. Misfolded Aß oligomers instigate conformation changes in other, normally folded Aß oligomers, increasing the number of misfolded proteins and eventually forming…
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ß-Amyloid Peptide (1-42), human
LKT LabsAmyloid-ß (Aß) is a peptide cleavage product of amyloid precursor protein (APP) that is often used as a biomarker in Alzheimer’s disease. Misfolded Aß oligomers instigate conformation changes in other, normally folded Aß oligomers, increasing the number of misfolded proteins and eventually forming…
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Bis(salicyl) Fumarate
LKT LabsBis(salicyl) fumarate is an aspirin analog that is used to induce hemoglobin chain crosslinks at lysine residues. This compound is used to study hemoglobin function in research models and may be used to develop treatments for sickle-cell anemia. This compound may exhibit anti-inflammatory,…
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Amikacin Disulfate
LKT LabsAmikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. Amikacin binds the 30S ribosomal subunit, preventing translation. Grade: ≥98%
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Ceftriaxone Sodium
LKT LabsCeftriaxone is a third generation β-lactam cephalosporin antibiotic. Ceftriaxone exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding protein activity to prevent peptidoglycan synthesis and bacterial cell wall formation. Ceftriaxone is…
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AK-7
LKT LabsAK-7 is an inhibitor of sirtuin 2 (SIRT2); sirtuins are considered class III histone deacetylases (HDACs). AK-7 exhibits neuroprotective activity, decreasing brain atrophy and improving motor function and survival in animal models of Huntington’s disea
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Chromium Picolinate
LKT LabsChromium picolinate is clinically used to decrease fasting blood glucose and insulin levels. Chromium picolinate exhibits anti-hyperlipidemic, cardioprotective, and anti-diabetic activities. In high-fat diet-fed rats, chromium picolinate decreases plasma lipid levels and platelet aggregation. In…
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Calcitonin gene-related peptide (CGRP) is an endogenous neuropeptide that exhibits anti-inflammatory, anti-resorptive, anxiogenic, neuroprotective, and pro-angiogenic activities. In animal models of livery injury, CGRP displays protective benefit, decreasing pro-inflammatory cytokine levels. CGRP…
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Bromhexine Hydrochloride
LKT LabsBromhexine is a synthetic derivative of vasicine that exhibits mucolytic and antioxidative activities. Bromhexine increases production of serous mucus, decreases mucus viscosity, and helps cilia transport mucus out of the lungs. Bromhexine is clinically used to treat respiratory disorders…
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2-tert-Butyl-4-Hydroxyanisole
LKT Labs2-Tert-butyl-4-hydroxyanisole (2-BHA) is one component of butylated hydroxyanisole (BHA). This compound is commonly used as a food additive; it exhibits antioxidative activity. 2-BHA acts as a phase II enzyme inducer, increasing levels of glutathione and glutathione-S-transferase.
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[Des-Asp1]-Angiotensin I, Human
LKT LabsAngiotensin I (AT I) is a peptide cleavage product of angiotensin and serves no primary biological purpose other than to function as a precursor to angiotensin II.
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Candesartan Celexetil Ester
LKT LabsCandesartan is an inhibitor of the angiotensin II type 1 receptor (AT1) that displays antihypertensive, cardioprotective, nephroprotective, and potentially antiviral activities. In vivo, candesartan increases renal blood blow and decreases renal vascular resistance, glomerular filtration rate, and…
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Besifloxacin Hydrochloride
LKT LabsBesifloxacin is a fourth generation fluoroquinolone antibiotic that displays broad-spectrum antibacterial activity against aerobic and anaerobic bacteria and is effective against a wide range of ocular pathogens that exhibit resistance to other fluoroquinolone antibiotics. Besifloxacin inhibits DNA…
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ß-Cembrenediol
LKT LabsCembrenediols are diterpenes originally found in Anisomeles. These compounds exhibit antibacterial activity against Mycobacterium and antifungal activity against Colletotrichum. Grade: ≥98%
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Benztropine Mesylate
LKT LabsBenztropine is an inhibitor of the dopamine transporter (DAT); it potentiates dopamine overflow in rat brain slices.
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L-Citrulline
LKT LabsL-Citrulline is a by product of NO formation from metabolism of L-arginine that exhibits tocolytic and antioxidative activities. L-Citrulline was originally found in watermelon. In isolated rat uteri, L-citrulline decreases uterine contractile force through stimulation of the NO-cGMP relaxant…
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Boc-RRR-AMC
LKT LabsThis peptide is a protease substrate that is used to measure protease activity in vitro. This peptide can bind to serine proteases such as cathepsins. Grade: ≥98%
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N-(4-Carbethoxyphenyl)retinamide
LKT LabsN-(4-Carbethoxyphenyl)retinamide is a retinoid that exhibits anticancer chemotherapeutic and chemopreventive activities. This compound inhibits development of stomach and oral cancers in vivo and shows some benefit in the treatment of dysplasias. Additionally, this compound induces differentiation…
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ARRY-162
LKT LabsARRY-162 is an orally bioavailable noncompetitive inhibitor of MEK1/2 and ERK that shows anticancer chemotherapeutic activity. Inhibition of MEK inhibits downstream signaling by IL-1, IL-6, and TNF. ARRY-162 inhibits proliferation in melanoma, non-small-cell lung cancer (NSCLC), head/neck cancer,…
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Cilostazol
LKT LabsCilostazol is a quinolone inhibitor of phosphodiesterase 3B (PDE 3B) that exhibits vasodilatory, antiplatelet, anti-inflammatory, anti-diabetic, antidepressant, anxiolytic, and pro-angiogenic activities. Cilostazol is clinically used to treat intermittent claudication associated with peripheral…
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Acetyl-L-Carnitine Hydrochloride
LKT LabsAcetyl-L-carnitine is a derivative of carnitine that enables functions of CoA and plays a significant role in the maintenance of energy homeostasis. Acetyl-L-carnitine exhibits antidepressant, neuroprotective, analgesic, and antinociceptive activities. In vivo, acetyl-L-carnitine acetylates p65,…
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Abamectin
LKT LabsF0F1-ATPase and adenine nucleotide translocator inhibitor and GABA receptor antagonist. It prevents mitochondrial respiration and decreases sperm count and motility. Grade: ≥70%
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3-tert-Butyl-5-Methoxycatechol
LKT Labs3-Tert-butyl-5-methoxy-catechol exhibits anticancer activity, inhibiting proliferation of leukemia cells. This compound may also induce cellular differentiation in vitro.
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ß-Casomorphin, human
LKT Labsß-Casomorphin is a peptide fragment of casein that exhibits antioxidative and anti-fibrotic activities. In vivo, ß-casomorphin improves high glucose-induced changes in oxidative enzyme secretion and activity. ß-Casomorphin also decreases urinary glucose and protein levels as well as serum creatine…