Biologicals Cell Culture-Biologics-Equipment Cell Culture Medium Additives Growth Factors-Cytokines
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Interferon gamma (IFN γ), is a type II interferon that provides immunity against bacterial, viral and protozoan infections. In its active form, IFN γ is a glycosylated, non-covalently linked homodimer of 29-32 kDa subunits. It is produced by a number of immune cell types including…
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Human EGF Protein
Qkine Ltd.Human EGF protein is a potent EGF-family growth factor used in many human and mouse organoid and stem cell culture systems including intestinal and tumor (cancer) organoid culture. A pure 6.3 kDa biologically active mature human epidermal growth factor. O
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GMP Human IL-7
GeminiBioGMP grade Recombinant Human Interleukin-7 (hIL-7) and IL-2,15 and 21 are members of the common ? chain cytokine family. Interleukin-7 is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells,…
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TGF-ß1 PLUS Protein
Qkine Ltd.Human/bovine/porcine TGF-ß1 PLUS protein is the first entirely animal-free recombinant human transforming growth factor beta 1 (TGF-ß1) protein for highly reproducible results and compatible with chemically-defined stem cell media. TGF-ß1 is used extensiv
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Recombinant Human Activin A Protein
Qkine Ltd.Human/mouse/rat/bovine/porcine activin A protein is a TGFß family growth factor used frequently for the maintenance of pluripotency in induced pluripotent stem cell (iPSC) and embryonic stem cell (ESC) culture. Recombinant human Activin A protein is also
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GMP Human FLT3 Ligand
GeminiBioIs a recombinant protein that is produced from E. coli and is designed to support basic, translational, and clinical research, as well as commercial applications, and offers: High biological activity verified by a relevant bioactivity assay with low endotoxin levels ≥ 97% purity with high…
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GMP Human IL-2 (c126s)
GeminiBioRecombinant Human Interleukin-2 (IL-2 C126S), also known as T cell growth factor (TCGF), is essential in promoting adaptive cellular immunity and tolerance, primarily via its direct effects on T cells. The major source of IL-2 is from activated CD4+ or activated CD8+ T cells. IL-2 also stimulates…
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GMP Human IL-15
GeminiBioGMP grade Recombinant Human Interleukin-15 (hIL-15) is a widely expressed proinflammatory cytokine structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells,…
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Recombinant FGF2-G3 (FGF2-STAB®) Protein
Qkine Ltd.Recombinant FGF2-G3 (FGF2-STAB®) protein is a thermostable engineered form of FGF-2 (bFGF). Qk053 is the 154 aa mature domain of FGF-2 (Qk027) with nine amino acid substitutions to enhance stability without impacting bioactivity developed by Dvorak et al.
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Corning® Growth Factor
CorningThe Corning portfolio of cytokines, growth factors, and media supplementation offers a wide array of proteins that result in proliferation or differentiation of the affected cells. Vialed, highly purified growth factors with high biological activity Broad range of highly purified natural and…
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Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts. GM-CSF is a hematopoietic growth factor that stimulates the…
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Humankine™ Recombinant Human IL-7
ProteintechAnimal-free Recombinant Human IL-7 is expressed in Human 293 cells as a highly glycosylated protein. Under reducing conditions, IL-7 migrates as three separate bands as 19 kDa, 25 kDa and 30 kDa. In comparison IL-7 produced in an E. coli expression system have glycosylation and migrate as a single…
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Bone morphogenetic protein-4 (BMP-4), also known as BMP2B and DVR4, belongs to the TGF-beta family. BMPs have been shown to promote astroglial differentiation both in vitro and in vivo. BMP-4 can also induce cartilage and bone formation (PMID 16234975). Xeno-free Recombinant Human BMP-4 is…
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Basic Fibroblast growth factor (FGFbasic), also known as bFGF, FGF2, FGF-β or HBGF-2, belongs to the FGF family. FGFbasic is involved in a number of biological processes including embryonic development and differentiation, neuron differentiation, survival, and regeneration, and the…
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Recombinant human R-spondin 1 protein (RSPO1) is the prototypic member of the R-spondin family and is used to potentiate Wnt signalling in many organoid culture systems including intestinal and tumor (cancer) organoid culture. R-spondin 1 is also required
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FMS-related tyrosine kinase 3 ligand (FLT3 Ligand) is a growth factor that regulates proliferation of early hematopoietic cells. FLT3 Ligand binds to cells expressing the tyrosine kinase receptor FLT3. FLT3 Ligand by itself does not stimulate proliferation of early hematopoietic cells, but…
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Interleukin-3 (IL-3) is a multilineage hematopoietic growth factor that promotes the proliferation, differentiation and survival of early multilineage hematopoietic progenitors. In particular, this cytokine plays a key role in stimulating the proliferation and survival of myeloid precursors. It is…
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Human BMP4 protein (bone morphogenetic protein 4) is a key regulator of embryogenesis and supports the differentiation of embryonic stem cells and induced pluripotent stem cells. In addition, BMP4 protein plays roles in the differentiation of mesenchymal
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GMP Human IL-21
GeminiBioGMP grade recombinant Human Interleukin-21 is a common ?-chain cytokine regulating many cell types of the immune system. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. IL-21 plays an important role in the development of…
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Coagulation factors are a group of related proteins that are essential for normal blood clotting (haemostasis). After an injury, clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Prothrombin circulates in the bloodstream in an inactive form until an…
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EGF (epidermal growth factor) is a 6 kDA, single chain protein that serves a mitogenic factor for numerous cell types, particularly epithelial cells and fibroblasts. It is predominantly produced and secreted by the kidneys in humans. EGF activates cells through binding with its corresponding…
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IL-15 is a 4-α-helix bundle cytokine playing a pivotal role in stimulation of both innate and adaptive immune cells. It is produced primarily by keratinocytes, skeletal muscle cells, monocytes, and CD4+ T cells. It is a member of the common gamma chain family. The members of the common gamma…
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TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, and cell differentiation. TGF acts synergistically with TGFA in inducing transformation process. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result…
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Cystatin C is a 13-kDa protein that is expressed globally in the body. In healthy individuals, glomerular filtration in the kidney maintains it at a safe level. When kidney function is impaired, Cystatin C levels rise quickly. This makes it an early and sensitive biomarker of renal dysfunction…
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Interferon alpha 2 is a type 1 interferon secreted by virus-infected cells to protect surrounding cells from the pathogen. Recombinant human interferon alpha 2 has been approved for therapeutic application in a range of human oncological and viral diseases. Three Interferon alpha 2 subvariants (2A,…
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Serum albumin is the most abundant protein in blood plasma and has a vast number of roles including oncotic pressure and detoxification. It has important applications in medicine, including treatment of trauma and blood loss (PMID 7027277, 2574367). HumanKine® GMP (Good Manufacturing…
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Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It…
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Hepatocyte growth factor (HGF) is the most potent mitogen of mature hepatocytes in primary culture. It is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin (PMID 1530787, 2531289). HGF exerts a variety of effects on several cells, such as…
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HumanKine® GMP (Good Manufacturing Practice) recombinant proteins are manufactured and validated in accordance with ISO 13485 quality management system and is compliant with GMP. Our GMP recombinant proteins are animal component free (ACF), xeno free (XF) and tag free (TF).
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Humankine™ Recombinant Human IL-2
ProteintechAnimal-free Recombinant Human IL-2 is an O-glycosylated, four alpha -helix bundle cytokine. It is expressed by gamma T cells, CD4+ and CD8+ T cells, eosinophils, B cells, and dendritic cells. IL-2 has potent stimulatory activity for antigen-activated T cells. It is a monomeric glycoprotein with an…
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Noggin is an inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. It is essential for cartilage morphogenesis and joint formation. Noggin inhibits chondrocyte differentiation through its interaction with GDF5 and GDF6…
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The transforming growth factor beta-3 (TGFβ-3) protein is found throughout the body and is required for development before birth and throughout life. TGFβ-3 binds to the receptor proteins on the surface of cells. This binding triggers the transmission of signals within the cell. As part…
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