Biologically Active Small Molecules
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Fluvoxamine (maleate)
Cayman ChemicalA selective serotonin reuptake inhibitor (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM); potentiates the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the CNS resulting in antidepressant effects.
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Abacavir (sulfate)
Cayman ChemicalAn antiviral analog of guanosine, inhibiting the reverse transcriptase of HIV type 1 with an IC50 value of 5.3 μM; blocks retroviral replication.
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Hydroxy Dimetridazole
Cayman ChemicalA metabolite of dimetridazole, the nitroimidazole-based antibacterial and anticoccidial agent suspected to be carcinogenic and mutagenic to humans.
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Aminoacetone (hydrochloride)
Cayman ChemicalA threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases; at 0.10-5 mM acts as a pro-oxidant inducing cell death in RINm5f pancreatic β-cells; used as a growth substrate for Pseudomonas.
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TBTA
Cayman ChemicalA tertiary amine that complexes with, and stabilizes, Cu(I) to accelerate azide-alkyne cycloadditions, as used in click chemistry.
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4-Pyrimidinecarboxaldehyde, dimethyl acetal
Cayman Chemical4-Pyrimidinecarboxaldehyde, dimethyl acetal is a synthetic intermediate useful for pharmaceutical synthesis.
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Acetyl Podocarpic Acid Anhydride
Cayman ChemicalA potent, semi-synthetic LXR agonist derived from extracts of the mayapple; induces the expression of the ABCA1 reverse cholesterol transporter to increase the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol (ED50 = 1 nM).
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L-Citrulline
LKT LabsL-Citrulline is a by product of NO formation from metabolism of L-arginine that exhibits tocolytic and antioxidative activities. L-Citrulline was originally found in watermelon. In isolated rat uteri, L-citrulline decreases uterine contractile force through stimulation of the NO-cGMP relaxant…
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Aspirin-50 g
Cayman ChemicalA non-selective, irreversible COX inhibitor with IC50 values of 0.75 and 1.25 mM for ovine COX-1 and COX-2, respectively.
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VPC 23019
Cayman ChemicalA competitive antagonist of S1P1 and S1P3 receptors (pKis = 7.86 and 5.93, respectively); inhibits S1P-induced migration of thyroid cancer cells, ovarian cancer cells, and neural stem cells.
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Bakuchiol
Cayman ChemicalA natural meroterpene that has retinol-like effects on gene expression and properties of the skin; has antioxidant and antibacterial actions; inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).
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2-phenyl-3-methyl-Quinoxaline
Cayman ChemicalA synthetic intermediate useful for pharmaceutical synthesis.
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AC-55541
Cayman ChemicalA selective PAR2 agonist that stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization in in vitro functional assays (pEC50s = 6.7, 5.9, and 6.6, respectively); elicits pronociceptive activity in vivo.
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Exendin-4 (acetate)
Cayman ChemicalA potent peptide agonist of the GLP-1 receptor (Ki = 136 pM); stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes; protects hippocampal neurons against glutamate-induced apoptosis.
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ß-Gal-NONOate
Cayman Chemicalβ-Gal-NONOate is a nitric oxide (NO) donor which releases NO following activation by β-galactosidase. β-Gal-NONOate is stabile in aqueous solution at neutral and acidic pH for several hours, exhibits good water solubility, and is able to cross the cell membrane. Following enzymatic…
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AS-703026
Cayman ChemicalSelectively inhibits MEK1/2; potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation (IC50s = 10 and 18.2 nM, respectively); 30 mg/kg reduced tumor growth significantly in mice bearing H929 MM xenografts.
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Betamethasone
LKT LabsBetamethasone is a glucocorticoid receptor agonist that exhibits anti-inflammatory, immunosuppressive, and anti-ulcerative activities. Betamethasone is clinically used to treat skin irritations such as psoriasis and to accelerate preterm fetal lung development.
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Amylose
Cayman ChemicalA polysaccharide made of α-D-glucose units that constitutes about 20% of starch; acts as an indicator, turning blue in the presence of iodine, and has also been coupled to magnetic beads for the isolation and purification of maltose-binding protein fusion proteins.
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(S)-(-)-Linoleyl-1'-Hydroxy-2'-Propylamide
Cayman ChemicalA homolog of LOEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.
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Sucrose hexasulfate (potassium salt)
Cayman ChemicalA polysulfated disaccharide that is used as a reference standard for sucralfate.
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Resazurin (sodium salt)
Cayman ChemicalA blue non-fluorescent dye that is used as an oxidation-reduction indicator in cell viability assays in a variety of cells; can be reduced to the highly red-fluorescent product resorufin (excitation: 530-540 nm; emission: 585-595 nm) and used as a quantifiable detection agent in enzyme activity or…
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CAY10678
Cayman ChemicalA benzoimidazole that potently inhibits human and rat recombinant mPGES-1 (IC50 = 0.09 and 0.9 µM, respectively); dose-dependently blocks PGE2 synthesis in isolated cells and whole blood treated with LPS or IL-1β; dose-dependently reduces PGE2 synthesis and cell recruitment…
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Zeaxanthin
Cayman ChemicalA dietary carotenoid present in the macula region of the eye; high dietary intake correlates with reduced risk of age-related macular degeneration.
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4-oxo-2-Nonenal
Cayman ChemicalA lipid peroxidation product; actively modifies histidine and lysine residues on proteins and causes protein cross-linking.
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Cinaciguat (hydrochloride)
Cayman ChemicalAn activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM); reduces hypertension, limits cardiomyocyte hypertrophy, protects against ischemia/reperfusion injury, and reduces morbidity and mortality in response to endotoxic shock.
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OG-L002
Cayman ChemicalA potent inhibitor of LSD1 (IC50 = 0.02 µM) that less effectively inhibits MAO-A and MAO-B (IC50s = 1.38 and 0.72 µM); blocks the expression of IE genes of HSV and hCMV in mammalian cells; represses HSV primary infection in mice and blocks HSV reactivation from…
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Tafluprost ethyl amide
Cayman ChemicalA more lipid soluble derivative of Tafluprost, a very potent FP receptor agonist (Ki = 0.4 nM).
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Y-27632 (hydrochloride)
Cayman ChemicalA potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK-II (IC50 = 800 nM); also inhibits PRK2 with an IC50 value of 600 nM.
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Salmeterol xinafoate
Cayman ChemicalA long-acting, selective β2-adrenergic agonist with bronchodilator actions (EC50 = 0.25 µM) that demonstrates 2,818-fold selectivity for β2-adrenergic receptors over β1-adrenergic receptors.
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Vitamin K3
Cayman ChemicalA precursor to Vitamin K2 that is capable of both redox cycling and arylating nucleophilic substrates by Michael addition; used as an antihemorrhagic agent and to inhibit the proliferation of various cancer cells.
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Sodium Valproate
MP BiomedicalsValproic Acid, Sodium Salt is a branched chain fatty acid which is reported to enhance central GABAergic neurotransmission and inhibit Na+ channels. Sodium Valproate is reported to cause inositol depletion, activate the ERK pathway, inhibit GSK-3α and GSK-3β. Valproic Acid has been…
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ICI 118551 (hydrochloride)
Cayman ChemicalA potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2 receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively); active in vivo and often used to evaluate the actions of adrenergic receptor agonists.
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