Biologically Active Small Molecules

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Biologically Active Small Molecules

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  • LKT Labs

    Bongkrekic acid is an antioxidative compound that inhibits mitochondrial respiration by preventing the mitochondrial permeability transition (MPT); it suppresses transport of ADP/ATP across the mitochondrial inner membrane, decreasing oxidative stress. Grade: ≥98%

  • Cayman Chemical

    A photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.

  • Cayman Chemical

    DepNA is one of several nitroaniline fatty acid amides which can be used to measure FAAH activity.{8928} FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate AEA. It also will hydrolyze fatty acid amides…

  • Cayman Chemical

    A mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml), preventing translocation of the enzymes on DNA; used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.

  • Cayman Chemical

    (S)-Naproxen is a non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively.

  • Cayman Chemical

    A toxin produced by cyanobacteria that inhibits the catalytic activity of protein phosphatases PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.

  • Azithromycin is an azalide macrolide antibiotic derived from erythromycin. Azithromycin binds the bacterial 50S ribosomal subunit, inhibiting protein translation. Azithromycin displays antibacterial, anti-fibrotic, and anti-inflammatory activities. In epithelial cells, azithromycin inhibits the…

  • Cayman Chemical

    A stable and efficient hole-transport material in organic light-emitting devices and in ssDSSCs; yields high ssDSSC efficiency due to its excellent pore-filling property into mesoporous titania films.

  • Cayman Chemical

    A potent activator of KCNQ1 (Kv7.1) channels (EC50 = 260 nM); EC50 > 30 µM for KCNQ2, KCNQ4, and hERG; potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments IKs current in cultured…

  • Cayman Chemical

    A natural isothiocyanate which induces the expression of phase II detoxification enzymes and activates Nrf2, promoting the expression of antioxidant and phase II genes; acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth…

  • A derivative of PGF2β with increased water solubility.

  • Cayman Chemical

    A FAHFA in which oleic acid occurs at the 12-position on hydroxy stearic acid.

  • Cayman Chemical

    A cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation; HRP combined with H2O2 causes luminescent peroxidation of luminol; can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.

  • Cayman Chemical

    CAS Number: 745046-84-8 Synonyms: Ivachtin Molecular Formula: C20H21N3O7S

  • Cayman Chemical

    A minor CYP450 metabolite of arachidonic acid that stimulates vasodilation of rabbit kidney.

  • Cayman Chemical

    A potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.

  • Cayman Chemical

    A highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC50 = 29 pM); rapidly suppresses autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells.

  • A fluorogenic substrate of β-glucuronidase that upon cleavage yields a blue fluorescent end product that can be monitored by UV light; typically used in the GUS reporter system for fluorescent detection of β-glucuronidase gene expression in E. coli and transformed plants.

  • Cayman Chemical

    Can be formed by the dimerization of two molecules of α-trans-cinnamic acid; significantly blocks inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.

  • Application Bafilomycin A1 is a valuable tool for distinguishing between different types of ATPases and inhibitor of endosomal acidification. Furthermore, Bafilomycin A1 was found to block lysosomal cholesterol trafficking in macrophages. Other Notes Bafilomycin A1 solution is provided…

  • Cayman Chemical

    A natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina; a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.

  • Cayman Chemical

    A dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1.

  • Cayman Chemical

    PGB1 is a non-enzymatic dehydration product of PGE1 resulting from treatment with strong base. Oligomers of PGB1 are known to exhibit antioxidant and ionophoric activity.

  • Cayman Chemical

    A natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 =…

  • Cayman Chemical

    An antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.

  • A selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors) that has sedative, antinociceptive, analgesic, and hypothermic actions; additive or synergistic with fentanyl-type opioids in reducing pain; has anesthetic sparing properties.

  • LKT Labs

    AK-7 is an inhibitor of sirtuin 2 (SIRT2); sirtuins are considered class III histone deacetylases (HDACs). AK-7 exhibits neuroprotective activity, decreasing brain atrophy and improving motor function and survival in animal models of Huntington’s disea

  • An internal standard for the quantification of 4-HNE mercapturic acid by GC- or LC-MS.

  • Cayman Chemical

    A cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors.

  • Cayman Chemical

    A cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments; blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.

  • Cayman Chemical

    A potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM); can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.

  • An F-series PG analog in which the C-1 carboxyl group has been modified to an N-diethyl amide; dialkyl amides such as a 17-p-PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids.

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