Biologically Active Small Molecules
-
2-Acetyl-5-tetrahydroxybutyl Imidazole
Cayman ChemicalAn inhibitor of S1P lyase; treatment of mice (50 µg/ml in drinking water) increases lymphoid tissue S1P concentrations 100-fold, reducing lymphocyte egress from thymus and peripheral lymphoid organs, resulting in reversible lymphopenia.
-
Adrenocorticotropic hormone (ACTH) is a peptide derived from proopiomelanocortin (POMC) processed and secreted in the pituitary gland. ACTH binds and activates melanocortin-2 (MC2) receptors, stimulating cortisol production in the adrenal cortex. ACTH exhibits anti-inflammatory and immunomodulatory…
-
Propylpyrazole Triol
Cayman ChemicalAn ERα selective agonist with a 410-fold relative binding affinity for ERα versus ERβ.
-
N1-Acetylspermine (hydrochloride)
Cayman ChemicalA monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.
-
Fatty Acid ethyl ester Standard Pack
Cayman ChemicalThe Fatty Acid ethyl ester Standard pack contains a series of nine fatty acid ethyl esters. Each pack contains 100 mg of the ethyl esters of the following fatty acids: stearic, myristic, linoleic, linolenic, arachidonic, oleic, palmitic, lauric, and palmitoleic.
-
1-Oxyl-2,2,5,5-tetramethylpyrroline-3-carboxylate NHS ester
Cayman ChemicalAn N-hydroxysuccinimide ester of the nitroxide spin label tempyo; an active acylating agent that preferentially targets α-amino groups, used to spin label proteins and aminoacylated RNA species.
-
Polymyxin B1
Cayman ChemicalA form of polymyxin B which terminates with 6-methyloctanamide; comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.
-
Aminoguanidine (hydrochloride)
Cayman ChemicalAminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.
-
WWL70
Cayman ChemicalA selective inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), a serine hydrolase that catalyzes the hydrolysis of 2-AG.
-
C-8 Ceramide
Cayman ChemicalC-8 ceramide is a cell-permeable analog of naturally occurring ceramides. Unlike C-2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels. For this reason, treatment of cells with C-8 ceramide may more closely mimic…
-
-
(+)-Abscisic Acid
Cayman ChemicalA plant hormone with diverse roles in disease resistance, plant development, and response to stresses; regulates gene expression and may contribute to epigenetic changes at the chromatin level.
-
Ruxolitinib
Cayman ChemicalA potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates…
-
Resminostat (hydrochloride)
Cayman ChemicalAn orally bioavailable inhibitor of HDAC1, HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells; abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 µM); dose-dependently…
-
GYY 4137
Cayman ChemicalA water-soluble, slow-releasing H2S donor which demonstrates vasodilator and anti-hypertensive activity in hypertensive rats when given intravenously; also protects against endotoxic shock in rats, inhibiting pro-inflammatory signaling.
-
-
Venturicidin A
Cayman ChemicalA macrolide antibiotic with antifungal activity; also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells; inhibits bacterial and mitochondrial ATP synthases.
-
Tamoxifen
Cayman ChemicalA selective estrogen receptor (ER) modulator; an ER antagonist in breast tissue, effective in treating early breast cancer; an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues.
-
Tetrodotoxin Citrate
Cayman ChemicalA potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through NaV channels (IC50s = 4.1 and 5.2 nM, respectively, in frog muscle and squid axon; Kd = 1.8 nM in rat brain), blocking nerve and muscle action potentials.
-
Chlorogenic Acid
Cayman ChemicalChlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean. Structurally, chlorogenic acid is the ester of caffeic acid with the 3-hydroxyl group of quinic acid. Chlorogenic acid is an important factor in plant metabolism.…
-
-
SRPIN340
Cayman ChemicalAn inhibitor of SRPK1 (Ki = 0.89 µM); suppresses the propagation of viruses in mammalian cells; modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.
-
AICAR
Cayman ChemicalA selective activator of AMPK; inhibits synthesis of fatty acids and sterols in hepatocytes and insulin-stimulated glucose uptake in adipocytes.
-
8-iso Prostaglandin E2
Cayman Chemical8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively. When infused into…
-
NADPH (sodium salt)
Cayman ChemicalThe reduced form of the electron acceptor NADP+ and acts as an electron donor in various biological reactions.
-
PF-04708671
Cayman ChemicalA specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM); does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity.
-
NFAT Inhibitor
Cayman ChemicalA cell-permeable, selective inhibitor of calcineurin-mediated dephosphorylation of NFAT that does not disrupt other calcineurin-dependent pathways; disrupts NFAT-dependent expression of IL-2 and TNF-α when transfected in Jurak T cells and prevents the activation and proliferation of T cells…
-
Aureothin
Cayman ChemicalA natural nitroaryl-substituted polyketide that exhibits antitumor, antifungal, and insecticidal activities; non-competitive inhibitor NADH:ubiquinone oxidoreductase of bovine heart, N. crassa, and E. coli (IC50s = 0.07, 0.08, and 22 nmol/mg protein, respectively).
-
Ciprofloxacin (hydrochloride)
Cayman ChemicalA fluoroquinolone antibiotic widely used as an antimicrobial and immunomodulatory agent; functions by inhibiting DNA A fluoroquinolone antibiotic widely used as an antimicrobial and immunomodulatory agent; functions by inhibiting DNA gyrase (a type II topoisomerase) and topoisomerase IV, the…
-
Cytochalasin B
Cayman ChemicalA cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments; blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.
-
Puerarin
Cayman ChemicalA natural isoflavone which is biotransformed by intestinal bacteria to give the phytoestrogens daidzein and equol, resulting in antithrombotic, antiallergic, and other salutary effects; modulates serotonin receptors when given intraperitoneally; suppresses LPS-mediated activation of NF-κB in…
-
Sodium Phosphate Stock Solution (500 mM, pH 9.0)
Cayman ChemicalSodium Phosphate Stock Solution (500 mM, pH 9.0) contains filtered 500 mM sodium phosphate buffer. It is ready to use as supplied.
