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| Section 1. Product and Company Identification |
| Product Name | 1,2,4-Trichlorobenzene, OmniSolv ® , For HPLC, Spectrophotometry | Product Code | TX1056 |
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| For More Information Call | In Case of Emergency Call |
| 856-423-6300 Technical Service
Monday-Friday: 8:00 AM - 5:00 PM |
800-424-9300 CHEMTREC (USA)
613-996-6666 CANUTEC (Canada) 24 Hours/Day: 7 Days/Week |
| Synonym | UNSYM-TRICHLOROBENZENE |
| Material Uses | Analytical reagent.
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| Chemical Family | Aromatic. |
| Section 2. Composition and Information on Ingredients |
| Component | CAS # | % by Weight |
| 1,2,4-Trichlorobenzene | 120-82-1 | 100 |
| Section 3. Hazards Identification |
| Physical State and Appearance | Liquid. (Colorless.) |
| Emergency Overview | DANGER!
HARMFUL IF SWALLOWED. MAY BE HARMFUL IF INHALED. CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. CONTAINS MATERIAL WHICH CAUSES DAMAGE TO THE FOLLOWING ORGANS: KIDNEYS, REPRODUCTIVE SYSTEM, LIVER, RESPIRATORY TRACT, SKIN, EYE, LENS OR CORNEA. BIRTH DEFECT HAZARD. CONTAINS MATERIAL WHICH CAN CAUSE BIRTH DEFECT. MAY REACT VIGOROUSLY WITH OXIDIZING AGENTS. |
| Routes of Entry | Inhalation. Ingestion. |
| Potential Acute Health Effects |
| Eyes | Hazardous in case of eye contact (irritant). Inflammation of the eye is characterized by redness, watering, and itching. |
| Skin | Hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Non-permeator by skin. |
| Inhalation | Hazardous in case of inhalation (lung irritant). May be hazardous in case of inhalation. |
| Ingestion | Hazardous in case of ingestion. |
| Potential Chronic Health Effects |
| Carcinogenic Effects | This material is not known to cause cancer in animals or humans. |
| Additional information See Toxicological Information (section 11) |
| Medical Conditions Aggravated by Overexposure: | Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. |
| Section 4. First Aid Measures |
| Eye Contact | Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention immediately. |
| Skin Contact | In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. |
| Inhalation | If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. |
| Ingestion | If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. |
| Section 5. Fire Fighting Measures |
| Flammability of the Product | May be combustible at high temperature. |
| Auto-ignition Temperature | 571.06°C (1059.9°F) |
| Flash Points | Closed cup: >109.9°C (229.8°F). |
| Flammable Limits | LOWER: 2.5% UPPER: 6.6% |
| Products of Combustion | These products are carbon oxides (CO, CO2), halogenated compounds. |
| Fire Hazards in Presence of Various Substances | Flammable in presence of open flames, sparks and static discharge, of heat, of oxidizing materials. |
| Explosion Hazards in Presence of Various Substances | Risks of explosion of the product in presence of static discharge:
Flammable in presence of open flames, sparks and static discharge. Explosive in presence of open flames, sparks and static discharge. Risks of explosion of the product in presence of mechanical impact: No. |
| Fire Fighting Media
and Instructions |
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet. |
| Protective Clothing (Fire) | Be sure to use an approved/certified respirator or equivalent. |
| Special Remarks on Fire Hazards | Not available. |
| Special Remarks on Explosion Hazards | Not available. |
| Section 6. Accidental Release Measures |
| Small Spill and Leak | Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. |
| Large Spill and Leak | Stop leak if without risk. If the product is in its solid form: Use a shovel to put the material into a convenient waste disposal container. If the product is in its liquid form: Do not get water inside container. Absorb with an inert material and put the spilled material in an appropriate waste disposal. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. |
| Spill Kit Information | No specific spill kit required for this product. |
| Section 7. Handling and Storage |
| Handling | Avoid contact with eyes, skin and clothing. Do not ingest. Avoid breathing vapors or spray mists. Keep container closed. |
| Storage | Keep container in a cool, well-ventilated area. |
| Section 8. Exposure Controls/Personal Protection |
| Engineering Controls | Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective occupational exposure limits. Ensure that eyewash stations and safety showers are proximal to the work-station location. |
| Personal Protection |
| Eyes | Splash goggles. |
| Body | Lab coat. |
| Respiratory | Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. |
| Hands | Gloves. |
| Feet | Not applicable. |
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| Personal Protection in Case of a Large Spill | Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. |
| Product Name | Exposure Limits |
| 1,2,4-Trichlorobenzene | Belgium Minister of Labour (Belgium, 1998). Skin
CEIL: 15.1 mg/m3 CEIL: 2 ppm VCD: 38 mg/m3 15 minute(s). VCD: 5 ppm 15 minute(s). VL: 15.1 mg/m3 8 hour(s). VL: 2 ppm 8 hour(s). DK-Arbejdstylsinet (Denmark, 1996). Skin GV: 15 mg/m3 8 hour(s). GV: 2 ppm 8 hour(s). 80/1107/EEC (Europe, 1996). Skin STEL: 5 mg/m3 15 minute(s). STEL: 37.8 ppm 15 minute(s). TWA: 2 mg/m3 8 hour(s). TWA: 15.1 ppm 8 hour(s). Tyterveyslaitos (Finland, 1998). STEL: 38 mg/m3 15 minute(s). STEL: 5 ppm 15 minute(s). TWA: 15 mg/m3 8 hour(s). TWA: 2 ppm 8 hour(s). INRS (France, 1996). VME: 40 mg/m3 8 hour(s). VME: 5 ppm 8 hour(s). National Authority for Occupational Safety/Health (Ireland, 1999). Skin OEL: 16 mg/m3 8 hour(s). OEL: 2 ppm 8 hour(s). Arbeidsinspectie (Netherlands, 1999). Skin TGG 15 min: 37.8 mg/m3 15 minute(s). TGG 15 min: 5 ppm 15 minute(s). TGG 8 uur: 15.1 mg/m3 8 hour(s). TGG 8 uur: 2 ppm 8 hour(s). N-Arbeidstylsinet (Norway, 1996). AN: 40 mg/m3 8 hour(s). AN: 5 ppm 8 hour(s). EH40-OES (United Kingdom (UK), 1997). STEL: 38 mg/m3 15 minute(s). STEL: 5 ppm 15 minute(s). TWA: 38 mg/m3 8 hour(s). TWA: 5 ppm 8 hour(s). ACGIH (United States, 1994). CEIL: 37 mg/m3 CEIL: 5 ppm NIOSH REL (United States, 1994). CEIL: 40 mg/m3 CEIL: 5 ppm OSHA Final Rule (United States, 1989). CEIL: 40 mg/m3 CEIL: 5 ppm |
| Section 9. Physical and Chemical Properties |
| Odor | Aromatic. |
| Color | Clear. |
| Physical State and Appearance | Liquid. (Colorless.) |
| Molecular Weight | 181.44 g/mole |
| Molecular Formula | C6-H3-Cl3 |
| pH | Not available. |
| Boiling/Condensation Point | 213.4°C (416.1°F) |
| Melting/Freezing Point | 16.9°C (62.4°F) |
| Specific Gravity | 1.45 (Water = 1) |
| Vapor Pressure | Not available. |
| Vapor Density | Not available. |
| Odor Threshold | 3 ppm |
| Evaporation Rate | Not available. |
| LogKow | Not available. |
| Solubility | Partially soluble in water. |
| Section 10. Stability and Reactivity |
| Stability and Reactivity | The product is stable. |
| Conditions of Instability | Not available. |
| Incompatibility with Various Substances | Reactive with oxidizing agents. |
| Rem/Incompatibility | Al |
| Hazardous Decomposition Products | carbon oxides (CO, CO2) , halogenated compounds |
| Hazardous Polymerization | Will not occur. |
| Section 11. Toxicological Information |
| RTECS Number: |
| 1,2,4 Trichlorobenzene | DC2100000 |
| Toxicity | Acute oral toxicity (LD50): 300 mg/kg [Mouse].
Acute dermal toxicity (LD50): 6139 mg/kg [Rat]. |
| Chronic Effects on Humans | DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [PROVEN]. |
| Acute Effects on Humans | Hazardous in case of eye contact (irritant). Inflammation of the eye is characterized by redness, watering, and itching. Hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Non-permeator by skin. Hazardous in case of inhalation (lung irritant). May be hazardous in case of inhalation. Hazardous in case of ingestion. |
| Synergetic Products (Toxicologically) | Not available. |
| Irritancy | Draize Test (Rabbit):
Skin: 1950mg/13w. Reaction: Moderate. |
| Sensitization | Not available. |
| Carcinogenic Effects | This material is not known to cause cancer in animals or humans. |
| Toxicity to Reproductive System | Classified Reproductive system/toxin/female, Reproductive system/toxin/male [PROVEN]. |
| Teratogenic Effects | Not available. |
| Mutagenic Effects | Tests on laboratory animals for mutagenic effects are cited in Registry of Toxic Effects of Chemical Substances (RTECS). |
| Section 12. Ecological Information |
| Ecotoxicity | Not available. |
| BOD5 and COD | Not available. |
| Toxicity of the Products of Biodegradation | The products of degradation are as toxic as the product itself. |
| Section 13. Disposal Considerations |
| EPA Waste Number | Not available. |
| Treatment | Material does not have an EPA Waste Number and is not a listed waste, however consultation with a permitted waste disposal site (TSD) should be accomplished. Always contact a permitted waste disposal (TSD) to assure compliance with all current local, state, and Federal Regulations. |
| + | Section 14. Transport Information |
| DOT Classification | Not available. |
| TDG Classification | Not available. |
| IMO/IMDG Classification | Not available. |
| ICAO/IATA Classification | Not available. |
| Section 15. Regulatory Information |
| U.S. Federal Regulations | TSCA 4(a) final test rules: 1,2,4-Trichlorobenzene
TSCA 8(b) inventory: 1,2,4-Trichlorobenzene TSCA 8(d) H and S data reporting: 1,2,4-Trichlorobenzene: 1982 TSCA 12(b) one time export: 1,2,4-Trichlorobenzene |
| SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: 1,2,4-Trichlorobenzene SARA 311/312 MSDS distribution - chemical inventory - hazard identification: 1,2,4-Trichlorobenzene: Immediate (Acute) Health Hazard, Delayed (Chronic) Health Hazard |
| SARA 313 toxic chemical notification and release reporting: 1,2,4-Trichlorobenzene |
| Clean Water Act (CWA) 307: 1,2,4-Trichlorobenzene |
| Clean Water Act (CWA) 311: No products were found. |
| Clean air act (CAA) 112 accidental release prevention: No products were found. |
| Clean air act (CAA) 112 regulated flammable substances: No products were found. |
| Clean air act (CAA) 112 regulated toxic substances: No products were found. |
| WHMIS (Canada) | Class D-1B: Material causing immediate and serious toxic effects (TOXIC).
Class D-2A: Material causing other toxic effects (VERY TOXIC). Class D-2B: Material causing other toxic effects (TOXIC). |
| CEPA DSL: 1,2,4-Trichlorobenzene |
| This product has been classifed in accordance with the hazard criteria of the Controlled Product Regulations and the MSDS contains all required information. |
| International Regulations |
| EINECS | 1,2,4-Trichlorobenzene 204-428-0 |
| DSCL (EEC) | R22- Harmful if swallowed.
R37/38- Irritating to respiratory system and skin. R41- Risk of serious damage to eyes. |
| International Lists | Australia (NICNAS): 1,2,4-Trichlorobenzene
Japan (MITI): 1,2,4-Trichlorobenzene Korea (TCCL): 1,2,4-Trichlorobenzene Philippines (RA6969): 1,2,4-Trichlorobenzene |
| China: No products were found. |
| State Regulations | Pennsylvania RTK: 1,2,4-Trichlorobenzene: (environmental hazard, generic environmental hazard)
Massachusetts RTK: 1,2,4-Trichlorobenzene New Jersey: 1,2,4-Trichlorobenzene |
| California prop. 65: No products were found. |
| Section 16. Other Information |
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| Changed Since Last Revision | + |
| Notice to Reader |
| The statements contained herein are based upon technical data that EMD Chemicals Inc. believes to be reliable, are offered for information purposes only and as a guide to the appropriate precautionary and emergency handling of the material by a properly trained person having the necessary technical skills. Users should consider these data only as a supplement to other information gathered by them and must make independent determinations of suitability and completeness of information from all sources to assure proper use, storage and disposal of these materials and the safety and health of employees and customers and the protection of the environment. EMD CHEMICALS INC. MAKES NO REPRESENTATION OR WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE, WITH RESPECT TO THE INFORMATION HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. |
